نتایج جستجو برای: 558 therefore

تعداد نتایج: 626325  

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2014
Jayakumar Surendradoss Thomas K H Chang Frank S Abbott

Acyl glucuronides are reactive electrophilic metabolites implicated in the toxicity of carboxylic acid drugs. Valproyl 1-O-β-acyl glucuronide (VPA-G), which is a major metabolite of valproic acid (VPA), has been linked to the development of oxidative stress in VPA-treated rats. However, relatively little is known about the toxicity of in situ generated VPA-G and its contribution to VPA hepatoto...

2014
Jayakumar Surendradoss Thomas K. H. Chang Frank S. Abbott

Acyl glucuronides are reactive electrophilic metabolites implicated in the toxicity of carboxylic acid drugs. Valproyl 1-O-b-acyl glucuronide (VPA-G), which is a major metabolite of valproic acid (VPA), has been linked to the development of oxidative stress in VPA-treated rats. However, relatively little is known about the toxicity of in situ generated VPA-G and its contribution to VPA hepatoto...

Journal: :Journal of Medical Imaging and Radiation Oncology 2012

Journal: :Biochemical and biophysical research communications 2002
Martin Knöpfel Marc Solioz

Iron and probably also copper are absorbed by the intestine in their reduced form. A b-type cytochrome, Dcytb, has recently been cloned from mouse and has been proposed to be the corresponding reductase. However, the nature of the cytochrome and the reduction reaction remain unknown. Here we describe the isolation and functional characterization of a novel b-type cytochrome from rabbit enterocy...

Journal: :Journal of the Royal Society of Medicine 1999

2017
P.W. Crous M.J. Wingfield T.I. Burgess G.E.St.J. Hardy P.A. Barber P. Alvarado C.W. Barnes P.K. Buchanan M. Heykoop G. Moreno R. Thangavel S. van der Spuy A. Barili S. Barrett S.O. Cacciola J.F. Cano-Lira C. Crane C. Decock T.B. Gibertoni J. Guarro M. Guevara-Suarez V. Hubka M. Kolařík C.R.S. Lira M.E. Ordoñez M. Padamsee L. Ryvarden A.M. Soares A.M. Stchigel D.A. Sutton A. Vizzini B.S. Weir K. Acharya F. Aloi I.G. Baseia R.A. Blanchette J.J. Bordallo Z. Bratek T. Butler J. Cano-Canals J.R. Carlavilla J. Chander R. Cheewangkoon R.H.S.F. Cruz M. da Silva A.K. Dutta E. Ercole V. Escobio F. Esteve-Raventós J.A. Flores J. Gené J.S. Góis L. Haines B.W. Held M. Horta Jung K. Hosaka T. Jung Ž. Jurjević V. Kautman I. Kautmanova A.A. Kiyashko M. Kozanek A. Kubátová M. Lafourcade F. La Spada K.P.D. Latha H. Madrid E.F. Malysheva P. Manimohan J.L. Manjón M.P. Martín M. Mata Z. Merényi A. Morte I. Nagy A.-C. Normand S. Paloi N. Pattison J. Pawłowska O.L. Pereira M.E. Petterson B. Picillo K.N.A. Raj A. Roberts A. Rodríguez F.J. Rodríguez-Campo M. Romański M. Ruszkiewicz-Michalska B. Scanu L. Schena M. Semelbauer R. Sharma Y.S. Shouche V. Silva M. Staniaszek-Kik J.B. Stielow C. Tapia P.W.J. Taylor M. Toome-Heller J.M.C. Vabeikhokhei A.D. van Diepeningen N. Van Hoa Van Tri M. N.P. Wiederhold M. Wrzosek J. Zothanzama J.Z. Groenewald Pedro W. Crous Johannes Z. Groenewald Anne D. van Diepeningen Anne-Cécile Normand Michael J. Wingfield Treena I. Burgess Giles E.St.J. Hardy Colin Crane Sarah Barrett Paul A. Barber Michael J. Wingfield Raja Thangavel Paul A. Barber Merje Toome-Heller Ratchadawan Cheewangkoon Paul W.J. Taylor Miroslav Kolařík Željko Jurjević Vit Hubka Michel Heykoop Gabriel Moreno Pablo Alvarado Rhudson H.S.F. Cruz Jefferson S. Góis Iuri G. Baseia María P. Martín Kentaro Hosaka Juan Julián Bordallo Antonio Rodríguez Asunción Morte Vicente Escobio John Zothanzama Josiah M.C. Vabeikhokhei Robert A. Blanchette Benjamin W. Held Charles W. Barnes Juan Ramón Carlavilla José Luis Manjón Alfredo Vizzini K.N. Anil Raj K.P. Deepna Latha Patinjareveettil Manimohan Alessio Barili Maria E. Ordoñez Jorge A. Flores Charles W. Barnes Fernando Esteve-Raventós Francisco José Rodríguez-Campo Pablo Alvarado Rahul Sharma Yogesh S. Shouche Alena Kubátová Miroslav Kolařík Vit Hubka Marcela Guevara-Suarez Josepa Gené Josep Guarro Deanna A. Sutton Nathan P. Wiederhold Marcela Guevara-Suarez Josepa Gené Josep Guarro Mahajabeen Padamsee Bevan S. Weir Peter K. Buchanan Susan van der Spuy Nicholas Pattison Megan E. Petterson Andrea Roberts Susan van der Spuy Liz Haines Tangaroa Butler Alberto M. Stchigel José F. Cano-Lira Julia Cano-Canals Carla R.S. Lira Adriene M. Soares Tatiana B. Gibertoni Leif Ryvarden Cony Decock Leif Ryvarden Cony Decock Hugo Madrid Cecilia Tapia Víctor Silva Mónica Lafourcade Ekaterina F. Malysheva Anna A. Kiyashko Santa O. Cacciola Federico La Spada Nguyen Van Hoa Marilia Horta Jung Bruno Scanu Francesco Aloi Mai Van Tri Thomas Jung Leonardo Schena Ivona Kautmanova Vaclav Kautman Marek Semelbauer Milan Kozanek Milagro Mata Pablo Alvarado Olinto L. Pereira Meiriele da Silva Alfredo Vizzini Bernardo Picillo Enrico Ercole Soumitra Paloi Arun Kumar Dutta Krishnendu Acharya Deanna A. Sutton Jagdish Chander Małgorzata Ruszkiewicz-Michalska Julia Pawłowska Marta Wrzosek Monika Staniaszek-Kik Maciej Romański Zsolt Merényi István Nagy Zoltán Bratek J. Benjamin Stielow

Novel species of fungi described in this study include those from various countries as follows: Australia: Banksiophoma australiensis (incl. Banksiophoma gen. nov.) on Banksia coccinea, Davidiellomycesaustraliensis (incl. Davidiellomyces gen. nov.) on Cyperaceae, Didymocyrtis banksiae on Banksia sessilis var. cygnorum, Disculoides calophyllae on Corymbia calophylla, Harknessia banksiae on Banks...

2011
Wenni Tong Qin Xue Yong Li Lubo Zhang

Running title: Fetal hypoxia and heart remodeling 12 13 14 15 Corresponding author: 16 Lubo Zhang, PhD 17 Center for Perinatal Biology 18 Division of Pharmacology 19 Department of Basic Sciences 20 Loma Linda University School of Medicine 21 Loma Linda, CA 92350 22 Tel: 909-558-4325 23 Fax: 909-558-4029 24 Email: [email protected] 25 26 27 Articles in PresS. Am J Physiol Heart Circ Physiol (August...

2008
Kotaprolu Naga Sudha Mohammed Shakira Paturi Prasanthi Nalla Sarika Ch Narasimha Kumar Padavala Ajay Babu

Cyclooxygenase-2 (COX-2) enzyme binds to arachidonic acid and releases metabolites that are used to induce pain and inflammation. COX-2 selective inhibitors such as celecoxib, rofecoxib and valdecoxib are currently used to reduce inflammatory response. However, they lack anti-thrombotic activity and hence lead to cardiovascular and renal liabilities apart from gastrointestinal irritation. There...

2016
Qian Wang Aihui Fan Yongjun Yuan Lixian Chen Xiaohua Guo Xuliang Huang Qiaobing Huang

Disorders of angiogenesis are related to microangiopathies during the development of diabetic vascular complications, but the effect of advanced glycation end products (AGEs) on angiogenesis and the mechanism has not been completely unveiled. We previous demonstrated that moesin belonging to the ezrin-radixin-moesin (ERM) protein family protein played a critical role in AGE-induced hyper-permea...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2012
A Wozniak P Rutkowski A Piskorz M Ciwoniuk C Osuch E Bylina J Sygut M Chosia J Rys K Urbanczyk W Kruszewski P Sowa J Siedlecki M Debiec-Rychter J Limon

BACKGROUND Majority of gastrointestinal stromal tumours (GISTs) are characterised by KIT-immunopositivity and the presence of KIT/platelet-derived growth factor receptor alpha (PDGFRA) activating mutations. PATIENTS AND METHODS Spectrum and frequency of KIT and PDGFRA mutations were investigated in 427 GISTs. Univariate and multivariate analysis of relapse-free survival (RFS) was conducted in...

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