The orally available novel small molecules PF06463922 [(10R)-7-amino12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8, 4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3carbonitrile] and PF06471402 [(10R)-7-amino-12-fluoro-2,10,16-trimethyl15-oxo-10,15,16,17-tetrahydro-2H-8,4-(azeno)pyrazolo[4,3-h][2,5,11] benzoxadiazacyclo-tetradecine-3-carbonitrile] are second-gener...

Architectural design – the art and science of designing space, building and the built environment – is a creative and complex task. It involves considerations of form (shapes, structure and configurations) and function (purposes and utilities). Whether form precedes function or vice versa (Janson, 1982; Anderson, 1987), the training and education of architects posits that successful design shou...

BACKGROUND AND PURPOSE The utility of patient self-administered health history questionnaires has been extensively studied in physician practice settings, but little such research has been done in populations germane to physical therapist practice. The purpose of this study was to document the accuracy of a self-administered questionnaire for collecting patients' history of illness, surgery, an...

BACKGROUND A growing evidence base implicates vitamin D, sun exposure and latitude in the aetiology of multiple sclerosis (MS), however there are less data on the associations of these variables with disease outcomes. METHODS We undertook a cross-sectional survey of over 2000 people with MS recruited through internet platforms, seeking self-reported data on geographical location, intentional ...

Background. Multiple sclerosis (MS) is an autoimmune inflammatory disease of central nervous system (CNS). MS affects quality of Life (QOL) due to physical disability and other associated problems. Disease-modifying agents like interferon beta (IFNB) have been widely utilized in this patient population; however, their frequency, route of administration, side effects, high cost, and also the que...