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Conclusion This conference reflected a growing recognition that a fundamental knowledge and understanding of neuroendocrine interactions with the immunological and nervous systems need to be further acquired and related directly to basic and clinical aspects of rheumatic diseases. Clinically productive research on these complex mechanisms necessitates collaboration between investigators from ma...
* This investigation was supported in part by a research grant from the National Institute of Health, U. S. Public Health Service. From the Department of Zoology and Entomology and the Department of Botany and Plant Pathology (No. 519), Ohio State University. 1 Beadle, G. W., Chem. Revs., 37, 15-96 (1945). 2 Irwin, M. R., Adv'. Genetics, 1, 133-159 (1947). * Fox, A. S., Genetics, 34, 647-664 (1...
This is a formalization of the soundness and completeness proper-ties for various efficient encodings of sorts in unsorted first-order logicused by Isabelle’s Sledgehammer tool.The results are reported in [1, §2,3] and the formalization itself ispresented in [2, §3–5]. Essentially, the encodings proceed as follows:a many-sorted problem is decorated with (as few as possib...
Vascular endothelial growth factor receptor-1/fms-related tyrosine kinase-1 (VEGFR-1/Flt-1) is a tyrosine kinase receptor that binds placental growth factor (PlGF). Flt-1 is also highly expressed in breast-cancer tissues and breast-cancer cell lines. However, the molecular mechanism by which Flt-1 promotes breast-cancer invasion and metastasis by binding to PlGF-1 is unclear. In this study, we ...
Neuropeptide Y (NPY) is thought to be co-released with catecholamines in response to major cardiovascular stresses, but its relation to the release of catecholamines in response to minor stresses has been less well described. We therefore studied the response of plasma NPY-like immunoreactivity (NPY-Li) levels to standing (10 min) in eight normal subjects and 11 patients with congestive heart f...
چکیده معضل چاقی به عنوان عارضه ای جدی برای زندگی بی تحرک و ماشینی، مورد توجه اغلب مراکز بهداشتی و درمانی دنیا قرار گرفته است. چاقی عامل زمینه ساز و در واقع عامل خطری برای بروز بیماری های قلبی - عروقی است که عموماً با کاهش طول عمر مورد انتظار و افزایش بیماری همراه است. هدف پژوهش حاضر تأثیر 12 هفته تمرینات ویبریشن کل بدن، تمرینات هوازی و تمرینات ترکیبی( هوازی و ویبریشن کل بدن) بر ترکیب بدنی زنان ...
The DNA helicase encoded by bacteriophage T7 consists of six identical subunits that form a ring through which the DNA passes. Binding of ssDNA is a prior step to translocation and unwinding of DNA by the helicase. Arg-493 is located at a conserved structural motif within the interior cavity of the helicase and plays an important role in DNA binding. Replacement of Arg-493 with lysine or histid...
SMYD2 is a lysine methyltransferase that catalyzes the monomethylation of several protein substrates including p53. SMYD2 is overexpressed in a significant percentage of esophageal squamous primary carcinomas, and that overexpression correlates with poor patient survival. However, the mechanism(s) by which SMYD2 promotes oncogenesis is not understood. A small molecule probe for SMYD2 would allo...
The molecular pathways that contribute to the proliferation and drug response of cancer cells are highly complex and currently insufficiently characterized. We have identified a previously unknown microRNA-based mechanism that provides cancer cells means to stimulate tumorigenesis via increased genomic instability and, at the same time, evade the action of clinically utilized microtubule drugs....
1 The Economic Environment . . . . . . . . . . . . . . . . . . . . . . . . 3 2 Representative Democracy . . . . . . . . . . . . . . . . . . . . . . . . . 5 2.1 Policy Choice . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2.2 Voting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 2.3 Campaigning . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2.4 Entr...
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