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INTRODUCTION Saxagliptin, sitagliptin, and vildagliptin are dipeptidyl peptidase-4 (DPP-4) inhibitors widely approved for use in patients with type 2 diabetes. Using a crossover design, the present study compared trough levels of DPP-4 inhibition provided by these agents in a single cohort of patients with type 2 diabetes. METHODS This was a randomized, placebo-controlled, open-label, five-pe...

Glucagon like peptide 1 (GLP-1), a blood glucose homeostasis modulating incretin, has been proposed for the treatment of type 2 diabetes mellitus (T2DM). However, native GLP-1 pharmacokinetics reveals low bioavailability due to degradation by the ubiquitous dipeptydil peptidase IV (DPP-IV) endoprotease. In this study, the glucosamine-based polymer chitosan was used as a cationic polymer-based i...

background: date palm pollen (dpp) and astragalus genus are used in some countries for the treatment of infertility. objective: this study was designed to investigate effects of dpp and astragalus ovinus (a.ovinus) on fertility in healthy adult male rats. materials and methods: thirty-six rats were divided into six groups (n=6) including control and five treatment groups. dpp (120, 240 and 360 ...

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BACKGROUND Prognostic tools to predict early postoperative motor function recovery (MFR) after thoracolumbar intervertebral disk herniation (IVDH) in paraplegic dogs represent an opportunity to timely implement novel therapies that could shorten recovery times and diminish permanent neurological dysfunctions. HYPOTHESIS Fractional anisotropy (FA) values obtained using diffusion tensor imaging...

7-But-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one (ER-319711) is a novel dipeptidyl peptidase (DPP)-IV inhibitor discovered in our laboratories. In this study, we have characterized this DPP-IV inhibitor in vitro and in vivo as an antidiabetic agent. The trifluoroacetate salt form of ER-319711, ER-319711-15, inhibited human DPP-IV with an IC(50) value of 0.089 mic...

background: there is a rapidly growing trend in the consumption of herbal remedies in the developing countries. the phoenix dactylifera date palm pollen (dpp) is used in the traditional medicine for male infertility. the aim of this study was to determine the effects of orally administered dpp on the reproductive system of adult male rats.   methods: fifty sprague-dawley rats were maintained ac...

Dentin sialoprotein (DSP) and dentin phosphoprotein (DPP; phosphophoryn) are two principal dentin-specific non-collagenous proteins. DPP is extremely acidic and is rich in aspartic acid and serine. By virtue of this structure, DPP may bind large amounts of calcium and may facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals. The func...