نتایج جستجو برای: 4d qsar

تعداد نتایج: 16746  

Journal: :Journal of chemical information and computer sciences 1998
Weida Tong David R. Lowis Roger Perkins Yu Chen William J. Welsh Dean W. Goddette Trevor W. Heritage Daniel M. Sheehan

Three different QSAR methods, Comparative Molecular Field Analysis (CoMFA), classical QSAR (utilizing the CODESSA program), and Hologram QSAR (HQSAR), are compared in terms of their potential for screening large data sets of chemicals as endocrine disrupting compounds (EDCs). While CoMFA and CODESSA (Comprehensive Descriptors for Structural and Statistical Analysis) have been commercially avail...

Journal: :Journal of computational chemistry 2008
Qishi Du Ri-Bo Huang Yu-Tuo Wei Li-Qin Du Kuo-Chen Chou

A new drug design method, the multiple field three-dimensional quantitative structure-activity relationship (MF-3D-QSAR), is proposed. It is a combination and development of classical 2D-QSAR and traditional 3D-QSAR. In addition to the electrostatic and van der Waals potentials, more potential fields (such as lipophilic potential, hydrogen bonding potential, and nonthermodynamic factors) are in...

Journal: :Journal of molecular graphics & modelling 2004
Rajarshi Guha Jon R Serra Peter C Jurs

A Kohonen self-organizing map (SOM) is used to classify a data set consisting of dihydrofolate reductase inhibitors with the help of an external set of Dragon descriptors. The resultant classification is used to generate training, cross-validation (CV) and prediction sets for QSAR modeling using the ADAPT methodology. The results are compared to those of QSAR models generated using sets created...

2013
Lakshmi Gangwar Mithilesh Tiwari S. K. Singh

In this paper the Multi-linear regression analysis has been applied for QSAR study. The relationship has been worked out between the Log 1/C values of a series of compounds and certain quantum chemical and energy descriptors. The QSAR studies of Triazines inhibiting dihydrofolate reductase based on quantum chemical and energy descriptors shows that among all the 28 QSAR models PA51 to PA 78, th...

2016
Pathomwat Wongrattanakamon Vannajan Sanghiran Lee Piyarat Nimmanpipug Supat Jiranusornkul

The data is obtained from exploring the modulatory activities of bioflavonoids on P-glycoprotein function by ligand-based approaches. Multivariate Linear-QSAR models for predicting the induced/inhibitory activities of the flavonoids were created. Molecular descriptors were initially used as independent variables and a dependent variable was expressed as pFAR. The variables were then used in MLR...

2014
Stefano Cassani

Insubria QSAR PaDEL-Descriptor model for prediction of Endocrine Disruptors Chemicals (EDC) Estrogen Receptor (ER)-binding affinity. 1.2.Other related models: J.Li and P.Gramatica. The importance of molecular structures, endpoints’ values, and predictivity parameters in QSAR research: QSAR analysis of a series of estrogen receptor binders, Mol. Divers. 14, 2010, pp 687-696. [8] 1.3.Software cod...

Journal: :Journal of chemical information and modeling 2008
Stephen R. Johnson

A general feeling of disillusionment with QSAR has settled across the modeling community in recent years. Most practitioners seem to agree that QSAR has not fulfilled the expectations set for its ability to predict biological activity. Among the possible reasons that have been proposed recently for this disappointment are chance correlation, rough response surfaces, incorrect functional forms, ...

2012
A. K. Pathak

Two dimensional quantitative structure activity relationship (QSAR) study on series of substituted 2-azetidinone derivatives was performed by using V-LIFE MDS 3.0 software. Several statistical expression for 2D QSAR were developed using statistical methods like multiple regeression, principle component regression, partial least square regression etc. Out of several models, the best five 2D QSAR...

2015
Iván Olier Crina Grosan Noureddin Sadawi Larisa N. Soldatova Ross D. King

Quantitative structure activity relationships (QSARs) are functions that predict bioactivity from compound structure. Although almost every form of statistical and machine learning method has been applied to learning QSARs, there is no single best way of learning QSARs. Therefore, currently the QSAR scientist has little to guide her/him on which QSAR approach to choose for a specific problem. T...

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