The methylation by 3,3-[~4C]dimethyl-l-phenyltriazene of nucleic acids in various rat tissues was investigated. Following a single s.c. injection of 3,3-['4C]dimethyl-l-phenyl triazene (50 mg/kg), approximately 40% of the radioactivity was subsequently exhaled as ~4CO2. Expiration of '4CO2, metabolic ]4C labeling of liver proteins, and formation of 7[~4C]methylguanine, the major reaction produc...

In many regions of the mammalian cerebral cortex, cells that share a common receptive field property are grouped into columns. Despite intensive study, the function of the cortical column remains unknown. In the squirrel monkey, the expression of ocular dominance columns is variable, with columns present in some animals and not in others. By searching for differences between animals with and wi...

SUMMARY Basic4Cseq is an R/Bioconductor package for basic filtering, analysis and subsequent near-cis visualization of 4C-seq data. The package processes aligned 4C-seq raw data stored in binary alignment/map (BAM) format and maps the short reads to a corresponding virtual fragment library. Functions are included to create virtual fragment libraries providing chromosome position and further inf...

Neurons in layer 4C in macaque striate cortex show a diier-ential change in receptive eld size and achromatic contrast sensitivity with depth, and exhibit orientation selective responses in the upper 4C sublayer. Using a computational model we rst demonstrate that the observed change in receptive eld size and contrast sensitivity can arise from a diierential convergence of aaerents from the P a...

The objective of the present study was to investigate the accuracy of percent body fat (%fat) estimates from dual-energy X-ray absorptiometry, air-displacement plethysmography (ADP), and total body water (TBW) against a criterion four-compartment (4C) model in overweight and obese children. A volunteer sample of 30 children (18 male and 12 female), age of (mean +/- SD) 14.10 +/- 1.83 yr, body m...

The aim of the study is to identify associations between dental anxiety and postoperative pain in patients undergoing extraction of horizontally impacted wisdom teeth.A total of 119 volunteers provided demographic data, and completed questionnaires, the State-Trait Anxiety Inventory (STAI), Chinese Index of Dental Anxiety and Fear (C-IDAF)-4C, and the Numeric Rating Scale (NRS) for pain.Mean SA...

Neural stem cells were suggested to migrate to and invade intracranial gliomas. In the presented studies, interactions of NE-4C embryonic neural stem cells were investigated with C6 and Gl261, LL and U87, glioblastoma cells or with primary astrocytes. Glioma-derived humoral factors did not influence the proliferation of stem cells. NE-4C-derived humoral factors did not alter the proliferation o...

BACKGROUND & OBJECTIVES Many methods are available for measuring body fat of an individual, each having its own advantages and limitations. The primary objective of the present study was to validate body fat estimates from individual methods using the 4-compartment (4C) model as reference. The second objective was to obtain estimates of hydration of fat free mass (FFM) using the 4C model. MET...

We report a unique isoform of PLC[beta]4 in rat, PLC[beta]4c, that has an additional 37nucleotide exon inserted between nucleotides 3459-3460 of the previously published PLC[beta]4a coding sequence. This insertion results in replacement of 22 amino acid residues at the carboxyl terminal tail of PLC[beta]4a with 41 unique residues. A human EST for PLC[beta]4 also contains this exon and this exon...

A novel anionic water-soluble pillar[5]arene (4C-WP5A) was synthesized via a convenient synthetic strategy of the direct cyclization of a functionalized hydroquinone monomer. The alkyl chain dependent affinities of ferrocenyl aminiums (FCn(+), n: carbon number) with 4C-WP5A are driven by hydrophobic interactions and desolvations with assisted C-H···π interactions and electrostatic interactions.