BACKGROUND Data from retrospective studies have suggested that there may be an interaction between fluconazole and nevirapine, increasing nevirapine concentrations and potentially leading to hepatotoxicity. METHODS This study was nested within a large double-blind placebo-controlled study designed to determine if primary prophylaxis with fluconazole (200 mg three times per week) could reduce ...

Several manufacturers have recently started to equip their hardware with security modules. These typically consist of smart cards or special microprocessors. Examples include the “Embedded Security Subsystem” within the recent IBM Thinkpad or the IBM 4758 secure co-processor board [4]. In fact, a large body of computer and device manufacturers has founded the Trusted Computing Group (TCG) [9] t...

Cell cycle regulators and signal transduction pathways can influence apoptotic sensitivity of tumor cells, and we previously described an association between EGFr overexpression, reduced DNA repair activity, and increased apoptotic sensitivity of ME-180 cervical carcinoma cells toward cis-diammedichloroplatinum (cDDP; K. Nishikawa, et al., Cancer Res., 52: 4758-4765, 1992). In the present study...

Research was conducted on the most polluted river system in Poland, impacted by active and historical mining. Bottom sediment, suspended particulate matter and river water were collected in 2014 from Przemsza river and its tributaries. Sampling points remained the same as those chosen in a 1995 study. This allowed the comparison of heavy metal accumulation in bottom sediment over a span of almo...

BACKGROUND Although the effectiveness of influenza vaccination in high-risk groups has been proven, vaccine coverage continues to be less than 50% in The Netherlands. To improve vaccination rates, data on the organizational factors, which should be targeted in population-based prevention of influenza, is essential. AIM To assess the organizational factors in Dutch general practice, which were...

BACKGROUND Antiretroviral preexposure prophylaxis is a promising approach for preventing human immunodeficiency virus type 1 (HIV-1) infection in heterosexual populations. METHODS We conducted a randomized trial of oral antiretroviral therapy for use as preexposure prophylaxis among HIV-1-serodiscordant heterosexual couples from Kenya and Uganda. The HIV-1-seronegative partner in each couple ...

BACKGROUND Chagas disease is currently prevalent in European countries hosting large communities from Latin America. Whether asymptomatic individuals at risk of Chagas disease living in Europe should be screened and treated accordingly is unclear. We performed an economic evaluation of systematic Chagas disease screening of the Latin American population attending primary care centres in Europe....

We present new attacks against the EMV financial transaction security system (known in Europe as “Chip and PIN”), specifically on the back-end API support for sending secure messages to EMV smartcards. EMV is the new electronic payment system designed by VISA and Mastercard and widely deployed throughout Europe in the last 12 months. It aims to eventually supersede magnetic-stripe systems. Cust...