Husted, Russell F., Rita D. Sigmund, and John B. Stokes. Mechanisms of inactivation of the action of aldosterone on collecting duct by TGF-b. Am. J. Physiol. Renal Physiol. 278: F425–F433, 2000.—The purpose of these experiments was to investigate the mechanisms whereby transforming growth factor-b (TGF-b) antagonizes the action of adrenocorticoid hormones on Na1 transport by the rat inner medul...

Dinenno, Frank A., Pamela P. Jones, Douglas R. Seals, and Hirofumi Tanaka. Age-associated arterial wall thickening is related to elevations in sympathetic activity in healthy humans. Am J Physiol Heart Circ Physiol 278: H1205–H1210, 2000.—Arterial wall hypertrophy occurs with age in humans and is a strong predictor of cardiovascular disease risk. The responsible mechanism is unknown, but data f...

Yuan, Y., M. J. Chandler, R. D. Foreman, and J. P. Farber. Effects of abdominal or cardiopulmonary sympathetic afferents on upper cervical inspiratory neurons. Am J Physiol Regulatory Integrative Comp Physiol 278: R1289– R1295, 2000.—Responses of upper cervical inspiratory neurons (UCINs) to abdominal visceral or cardiopulmonary sympathetic stimulation were studied using extracellular recording...

Webster, Daniel R., and Darby L. Patrick. Beating rate of isolated neonatal cardiomyocytes is regulated by the stable microtubule subset. Am J Physiol Heart Circ Physiol 278: H1653–H1661, 2000.—We investigated the roles of microtubule (MT) dynamics (growth and shrinkage), the stable, nongrowing MT subset, the posttranslationally detyrosinated MT subset, and artificially elevated tubulin levels ...

Hering-Smith, Kathleen S., Cecilia T. Gambala, and L. Lee Hamm. Citrate and succinate transport in proximal tubule cells. Am. J. Physiol. Renal Physiol. 278: F492–F498, 2000.—Urinary citrate, which inhibits calcium nephrolithiasis, is determined by proximal reabsorption via an apical dicarboxylate transporter. Citrate is predominantly trivalent at physiological pH, but citrate22 is transported ...

We consider the survivability of planetary systems in the globular cluster 47 Tucanae. We compute the cross sections for the breakup of planetary systems via encounters with single stars and binaries. We also compute the cross sections to leave planets on eccentric orbits. We find that wider planetary systems (d > ∼ 0.3 AU) are likely to be broken up in the central regions of 47 Tucanae (within...

Eddinger, T. J., A. A. Korwek, D. P. Meer, and J. J. Sherwood. Expression of smooth muscle myosin light chain 17 and unloaded shortening in single smooth muscle cells. Am J Physiol Cell Physiol 278: C1133–C1142, 2000.—These experiments were performed to test the hypotheses that myosin light chain 17 (MLC17) a and b isoform expression varies between individual vascular smooth muscle (SM) cells a...

Yoo, Kee Hwan, Barbara A. Thornhill, and Robert L. Chevalier. Angiotensin stimulates TGF-b1 and clusterin in the hydronephrotic neonatal rat kidney. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R640–R645, 2000.—Unilateral ureteral obstruction (UUO) induces activation of the renin-angiotensin system and upregulation of transforming growth factor-b1 (TGF-b1; a cytokine modulating ce...

HAMID M. SAID, ALVARO ORTIZ, MARY PAT MOYER, AND NORIMOTO YANAGAWA Veterans Affairs Medical Center, Long Beach 90822; Veterans Affairs Medical Center, Sepulveda 91343; Departments of Medicine and Physiology/Biophysics, University of California at Irvine, Irvine 92697; Department of Medicine, University of California at Los Angeles, Los Angeles, California 90024; and INCELL Corporation, San Anto...

Panchenko, Maria V., Harrison W. Farber, and Joseph H. Korn. Induction of heme oxygenase-1 by hypoxia and free radicals in human dermal fibroblasts. Am. J. Physiol. Cell Physiol. 278: C92–C101, 2000.—Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme catabolism and presumably is involved in cellular iron homeostasis. It is induced by a variety of cellular stresses, including oxyge...