See related article by Presta et al., Cancer Res 1997;57:4593–99. The highlighted article describes the engineering of a molecule that for the first time allowed testing the hypothesis that blocking VEGF-mediated angiogenesis may confer a benefit on human patients (1). Twenty years later, the reagent described in our study, known today as bevacizumab or Avastin, represents a standard of therapy...

BACKGROUND Although dyslipidemia and hypertension occur together more often than can be explained by chance, few studies have carefully explored the nature of the relationship between plasma lipid levels and the risk of developing hypertension. METHODS We conducted a prospective study of 16 130 middle-aged and older female health professionals in 1992 who provided baseline blood samples and h...

A narrow zone of plasma membrane between the head and body of a protozoan from termites undergoes continual in-plane shear because the head rotates continuously in the same direction relative to the cell body (Tamm, S.L., and S. Tamm, 1974, Proc. Natl. Acad. Sci. USA 71:4589-4593). Using filipin and digitonin as cytochemical probes for cholesterol and related 3-beta-hydroxysterols, we found a h...

To determine the effect of a transient doe-litter separation (48 h) on milk production and feed intake from 1 to 21 days post-partum, a control group (C) in which litters had free access to nursing, and a biostimulated group (B) in which litters were separated from their does from d 9 to d 11 post-partum were used. Total milk production was higher in (C) than in (B) does (5090+/-1.1 g vs. 4593+...

A significant fraction of planetary nebulae (PNe) show jet-like features. These features are usually interpreted as fast collimated outflows, although their true space velocities are uncertain, as their measured radial velocities cannot be properly corrected for projection effects. We have compiled the measured expansion velocities and radial distances of collimated outflows for a sample of 33 ...

We develop practical tests for the global stability of interior fixed points for discrete-time competitive population models. Our method constitutes the extension to maps of the Split Lyapunov method developed for differential equations. We give ecologically-motivated sufficient conditions for global stability of an interior fixed point of a competitive map of Kolmogorov form, and show how thes...

BACKGROUND Esophageal cancer (EC) and gastric cancer (GC) are common cancers and leading causes of cancer deaths worldwide. Many studies have investigated the association between dietary flavonols intake and the risk of EC and GC, but the results are inconsistent. Hence, we conducted a systematic analysis of relevant population-based studies to assess the association and derive a more precise e...

Recent theoretical work on mild segmentation suggests that tests of dual listing should be conducted as joint tests: (a) a test of changes in market integration that may a€ect asset returns through investors portfolio reallocations as the choice set changes, and (b) a test of changing risk premium/information e€ects. Previous empirical studies on common stocks have been unable to identify signi...

Case 1. III.2 (Fig.), a 10-year-old Caucasian male, was first seen at the University of Kansas Medical Center in September 1968, complaining of uncontrollable movements. He was the product of a full-term gestation and uneventful delivery with a birthweight of 4593 g. Other than the main complaint, growth and development had been normal. He had the usual childhood diseases without a history sugg...