The age at menarche and several menstrual symptoms were reported by 516 Portuguese school girls who took part in a cross-sectional anthropometric study in Coimbra, Portugal. The mean ages of menarche calculated using the recall method and also using probit analysis were 12.53 +/-1.27 and 12.03 +/- 1.26 years, respectively. Parents'educational level, place of residence and size of the family did...

Results A total of 20’709 measurements (10’058 girls, 10’651 boys) were available for the analysis. The median age (range) was 9.92 years (3.25-18.33) for girls and 10.00 years (2.8318.67) for boys. The mean inter-incisal distance (range) was 45 mm (25-69) for girls and 45 mm (25-70) for boys. Age related percentiles were created for girls and boys separately, showing the 3, 10, 25, 50, 75, 90,...

OBJECTIVE McCune-Albright syndrome (MAS) is a rare disorder with a broad spectrum including precocious puberty (PP) due to recurrent estrogen-secreting ovarian cysts. This study evaluates the long-term safety and efficacy of letrozole treatment in large cohort of girls with MAS-associated PP. DESIGN Retrospective cohort analysis. METHODS Clinical data, including history and physical examina...

The aim of this study was to determine cognitive and motor status factors in female and male children aged 10-14, as well as developmental and/or integration functions according to gender. The study included 162 girls and 134 boys aged 10-14, divided into four groups: 84 girls aged 10-12 (mean age 11.26, SD 0.68), 84 boys aged 10-12 (mean age 11.41, SD 0.50), 78 girls aged 13-14 (mean age 13.52...

Accidental contamination of the Michigan food chain with polybrominated biphenyls (PBBs) led to the exposure of more than 4,000 individuals in 1973. Because PBB exposure is suspected to disrupt endocrine function, we assessed pubertal development in females 5-24 years of age (N = 327) who were exposed to PBB in utero and, in many cases, through breastfeeding. We estimated in utero PBB exposure ...

BACKGROUND Early sexual maturation has been associated with overweight that may persist after the completion of biological growth and development. We have prospectively examined the influence of early sexual maturation on subsequent overweight in late adolescence and assessed if this association was modified by central adiposity in early adolescence. METHODS 1605 Norwegian adolescents were fo...

BACKGROUND Little is known about the possible deleterious effects of phthalate exposure on endogenous sex steroid levels in children. OBJECTIVE Our objective was to investigate whether urinary phthalate metabolite levels are associated with circulating adrenal androgen levels and age at puberty. METHODS This was a longitudinal study of 168 healthy children (84 girls) examined every 6 months...

OBJECTIVE To determine the relationship between anthropometric indices and the age of menarche in female students of Sabzevar, Iran. METHODS The cross-sectional study was conducted in Sabzevar, Iran, from April to September 2010, and involved girls of 11-18 years of age. The required sample size for analysing the relationship between menarche age and Body Mass Index was estimated to be 110 by...

Menarche is a significant marker of maturity and puberty in girls, it transition influenced by different biophysical factors. This study was carried out to determine the age, seasons influence body mass index (BMI) on menarche. A total 450 girls’ between ages 10 19 years participated study. Age at menarche obtained via recall quo cross sectional method. Parameters measured were; standing height...

OBJECTIVE To assess secular trends in menarcheal age between 1973 and 1994 and to determine whether childhood levels of height, weight, and skinfold thicknesses can account for racial (white/black) differences in menarcheal age. METHODS Data from 7 cross-sectional examinations of school-aged children, with menarcheal age obtained through interviews, were used for both cross-sectional (11 218 ...