The method of electrophilic intramolecular cyclization is widely used for the synthesis condensed thienopyrimidine derivatives. In this work, regioselectivity process terminally substituted allylic derivatives, but-1-enyl and propargyl thioethers with p-methoxyphenyltellurttrichloride was investigated.
 It established that as a result tellurium-induced butenyl 5,6-dimethyl-3-phenylthieno[2...

Five new spiro[indoline-3,3′-indolizine]s have been synthesized with high regio- and stereospecificity in one-pot three-component reactions between a substituted indole-2,3-dione, ( S )-pipecolic acid trans -3-benzoylacrylic acid, subsequently characterized using combination of elemental analysis, IR 1 H 13 C NMR spectroscopy, mass spectrometry crystal structure analysis. (1′ SR ,2′ ,3 RS ,8a′ ...

The chemiluminescence of stimulated cells with phorbol myristate acetate and the production of nitric oxide after stimulation with lipopolisaccharide in the presence of the parent compounds FAA (flavone-8-acetic acid = (4-oxo-2phenyl-4H-chromen-8-yl)acetic acid), XAA (xanthone-4-acetic acid = (9-oxo-9Hxanthen-4-yl)acetic acid), and appropriate xanthone derivatives (1–7) was determined. Also the...

1. A branched-chain 2-oxo acid dehydrogenase was partially purified from ox liver mitochondria. 2. The preparation oxidized 4-methyl-2-oxopentanoate, 3-methyl-2-oxobutyrate and D- and L-3-methyl-2-oxopentanoate. The apparent Km values for the oxo acids and for thiamin pyrophosphate, CoA, NAD+ and Mg2+ were determined. 3. The oxidation of each oxo acid was inhibited by isovaleryl (3-methylbutyry...

The reaction of 1 H -benzoimidazole-2-carbaldehyde with 4-oxo-2-thioxothiazolidin-3-ylcarboxilic acids was studied and the combinatorial library 5-(1 -benzoimidazol-2-ylmethylene)-4-oxo-2-thioxothiazolidin-3-ylcarboxilic has been prepared. structures target compounds 8a-f , 9 10a, b were confirmed by using NMR spectroscopy elemental analysis. synthesized selected National Cancer Institute (NCI)...

New complexes of nickel (II) have been synthesized in the reaction mixture of nickel (II) acetate and 4-hydroxy-2-oxo-2Hchromene-3-carboxamide. Bis(4-hydroxy-2-oxo-2H-chromene-3carboxamidato-O,O)nickel (II) and diaquabis(4-hydroxy-2-oxo-2Hchromene-3-carboxamidato-O,O)nickel (II) were characterized by elemental analysis, IR spectroscopy and ESI mass spectrometry. Elemental analysis and mass spec...