In the title mol-ecule, C(24)H(20)N(2)O(4), the five-membered oxadiazole ring is nearly planar (r.m.s. deviation = 0.053 Å) and the phenyl ring of the biphenyl unit attached to it forms a dihedral angle of 73.2 (1)°; the other phenyl ring is close to coplanar with the oxadiazole ring [dihedral angle = 6.2 (2)°].

Two novel series of unsymmetrically substituted 1,2,4-oxadiazole viz., R.Ox.C(*)C n compounds are synthesized and characterized. An optically active, (S)-(+)-methyl 3-hydroxy-2-methylpropionate is used to introduce a chiral center in the molecule. A biphenyl moiety prepared by Suzuki coupling reaction is directly attached to the oxadiazole core at C-5 position. Investigations for the phase beha...

A series of five membered heterocyclics was synthesized by the reaction between isoniazid and various substituted isothiocyanates and was tested for their anticonvulsant activity by determining their ability to provide protection against convulsions induced by electroconvulsometer. Among the synthesized compounds, (IIf) 2-(4-chlorophenyl)amino-5-(4-pyridyl)-1,3,4-thiadiazole and (IIIf) 2-(4-chl...

Rapid and highly efficient synthesis of 2- or 2,5-substituted 1,3,4-oxadiazoles by the condensation of aryl carboxylic acid hydrazides and orthoesters can be achieved under microwave irradiation using an unmodified commercial over in unsealed vessels.

rapid and highly efficient synthesis of 2- or 2,5-substituted 1,3,4-oxadiazoles by the condensation of aryl carboxylic acid hydrazides and orthoesters can be achieved under microwave irradiation using an unmodified commercial over in unsealed vessels.

In the title compound, C(36)H(44)N(4)O(4)S, the dihedral angles between the central thio-phene ring and the pendent oxadiazole rings are 12.7 (2) and 13.7 (2)°, and the dihedral angles between the oxadiazole rings and their adjacent benzene rings are 6.1 (2) and 17.5 (2)°. An intra-molecular C-H⋯O inter-action may help to establish the conformation.

The compound, C(32)H(28)N(4)O(5), which was synthesized by the reaction of 2,5-bis-(2-hydroxy-lphen-yl)-1,3,4-oxadiazole with N-benzyl-2-chloro-acetamide, lies on a twofold rotation axis which passes through the mid-point of the N-N bond and the O atom of the oxadiazole unit. The phenyl-ene and oxadiazole rings are almost coplanar [dihedral angle 1.67 (5)°]. The structure is stabilized by intra...

New 5-(2-thienyl)-1,2,4-triazoles and 5-(2-thienyl)-1,3,4-oxadiazoles namely, N-[3-mercapto-5-(2-thienyl)-1,2,4-triazol-4-yl]-N'-arylthioureas 4a-e, 2-arylamino-5-(2-thienyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles 5a-e, 3-arylaminomethyl-5-(2-thienyl)-1,3,4-oxadiazoline-2-thiones 7a-e, 3-(N-substituted anilinomethyl)-5-(2-thienyl)-1,3,4-oxadiazoline-2-thiones 8a, b and 3-(4-substituted-1-pipe...

The search for better antimicrobial agent due to rapid appearance of multidrug resistant microorganism and antimicrobial properties of semicarbazones and 2,5-disubstituted 1,3,4-oxadiazoles prompted us to undertake the synthesis of a few novel N-[5-(4-substitutedphenyl)-1,3,4-oxadiazol-2-yl]-N-(4substitutedbenzaldehyde)-semicarbazone and N-[5-(4-substitutedphenyl)-1,3,4-oxadiazol-2-yl]-N-[1-(4s...

In the title compound, C(33)H(26)Cl(3)N(3)OS, the oxadiazole, piperidine and benzothia-pezine rings adopt envelope, chair and twist-boat conformations, respectively. In the crystal, the mol-ecular aggregation is characterized by chains of centrosymmetrically related pairs connected through Cl⋯Cl inter-actions [3.533 (2) Å], extending parallel to (202).