OBJECTIVES This study evaluated the mortality experience of workers from the styrene-butadiene rubber industry. Concerns about a possible association of 1,3-butadiene and styrene with lymphohaematopoietic, gastrointestinal, and lung cancers prompted the investigation. METHODS A retrospective follow up study was conducted of 15,649 men employed for at least one year at any of eight North Ameri...

A series of [M (R2PC2H4PR:)(butadiene)] com plexes of Ni, Pd and Pt has been prepared and their structures investigated NMR-spectroscopically. The nickel and palladium com plexes, irre­ spective of the substituents at phosphorus, contain a fluxional ?/2-bonded butadiene m olecule. In the case of platinum the bonding mode is ligand dependent: an ^-arrangem ent is observed where R is tert-butyl o...

The possibility of using the cation-exchange resin Lewatit K2420 as a catalyst for synthesis 1,3-butadiene from isopropyl alcohol and formaldehyde solution in one technological stage has been shown. regularities process have established influence form (a cyclic trimer 1,3,5-trioxane 37% water) on composition reaction mass yield main by-products assessed. It shown that heterogeneous showed catal...

To date, epidemiologic research on 1,3-butadiene has consisted of cohort mortality studies of workers in the styrene-butadiene rubber (SBR) and butadiene monomer industries. These studies have been extremely useful both in defining the focus on human health effects to the lymphopoietic cancers and in providing a perspective on which to evaluate the available animal models for human risk assessm...

Previous studies have revealed marked differences in the incidence of leukemia between rats and mice exposed to 1,3-butadiene that do not appear to be readily explained on the basis of pharmacokinetics or metabolism. Chronic exposure to 1,3-butadiene results in a high incidence of thymic lymphoma in B6C3F1 mice that is not observed in Sprague-Dawley rats. Studies at the Chemical Industry Instit...

1,2,3,4-Diepoxybutane (DEB) is considered the ultimate carcinogenic metabolite of 1,3-butadiene, an important industrial chemical and environmental pollutant present in urban air. Although it preferentially modifies guanine within DNA, DEB induces a large number of A --> T transversions, suggesting that it forms strongly mispairing lesions at adenine nucleobases. We now report the discovery of ...

The International Agency for Research on Cancer has given the designations of "sufficient evidence" of carcinogenicity of 1,3-butadiene in experimental animals and "limited evidence" of carcinogenicity in humans. To investigate the carcinogenic effect in humans, we conducted a cohort mortality study among 364 men who were assigned to any of three 1,3-butadiene production units located within se...

1,3-Butadiene, a major ingredient of synthetic rubber, has been shown to be carcinogenic in two animal species. To assess the possible human carcinogenicity of 1,3-butadiene, a critical review was undertaken of the epidemiologic literature. An early retrospective study of 8017 males employed in tire manufacturing found excess mortality for lymphatic and hematopoietic neoplasms in production wor...

The reactions between the phenyl radical (C(6)H(5)) and 1,3-butadiene (CH(2)CHCHCH(2)) together with its D6- and D4-isotopologues were studied under single collision conditions. The scattering data suggest that the reaction proceeds via indirect scattering dynamics and is initiated by an addition of the phenyl radical to the terminal carbon atom of the 1,3-butadiene molecule to form a C(6)H(5)C...