نتایج جستجو برای: 375

تعداد نتایج: 6827  

Journal: :Astronomy & Astrophysics 2007

2014
Yuanming Shen Jiansong Zhou Yang Li Feng Ye Xiaoyun Wan Weiguo Lu Xing Xie Xiaodong Cheng Zhi-Ming Zheng

Acquired chemo-resistance is one of the key causal factors in cancer death. Emerging evidences suggest that miRNA and epithelial-mesenchymal transition play critical roles in the chemo-resistance in cancers. Here, we showed the association of paclitaxel-resistance with miR-375 over-expression and epithelial-mesenchymal transition inducement in cervical cancer. Using different cervical cancer ce...

2015
Wen Shi Jing Yang Siyuan Li Xiaofeng Shan Xiaosong Liu Hong Hua Chuanke Zhao Zhendong Feng Zhigang Cai Lihe Zhang Demin Zhou

To elucidate the genetic effect involved in the premalignant progression of chronic inflammation to cancer, we performed microRNA and mRNA profiling in oral lichen planus (OLP), oral squamous cell carcinoma (OSCC), and normal tissue from the same patients. We demonstrate the involvement of a suppressive microRNA, miR-375, in the regulation of this premalignant progression via KLF5, a transcript...

Journal: :Journal of immunology 2013
Bertram Bleck Gabriele Grunig Amanda Chiu Mengling Liu Terry Gordon Angeliki Kazeros Joan Reibman

Air pollution contributes to acute exacerbations of asthma and the development of asthma in children and adults. Airway epithelial cells interface innate and adaptive immune responses, and have been proposed to regulate much of the response to pollutants. Thymic stromal lymphopoietin (TSLP) is a pivotal cytokine linking innate and Th2 adaptive immune disorders, and is upregulated by environment...

2016
Lucien Marchand Audrey Jalabert Emmanuelle Meugnier Kathleen Van den Hende Nicole Fabien Marc Nicolino Anne-Marie Madec Charles Thivolet Sophie Rome

Background. The use of miRNAs as biomarkers for Type 1 Diabetes (T1D) risk is attractive as T1D is usually diagnosed in front of acute symptoms. As miR-375 is highly expressed in the endocrine pancreas, we postulated that its circulating level might reflect beta cell alterations and might be altered in the blood of T1D patients recently diagnosed. Methods. Sera were obtained from 22 T1D childre...

2017
Dafei Xie Peiwen Yuan Dong Wang Hua Jin Hui Chen

The purpose of this study was to investigate the expression of miR-375 and miR-221 in liver cancer, and examine the correlations with pathological parameters and prognosis. We collected tumors and tumor-adjacent normal tissue from 70 patients with liver cancer admitted to the Department of General Surgery of Zhejiang Hospital. The expression of miR-375 by RT-qPCR was significantly lower in live...

2012
Warwick F. Vincent Antonio Quesada

13.4 Mat-Forming Species .................................................... 375 13.4.1 Community Structure ...................................................... 375 13.4.2 Mat Structure and Pigments ............................................ 377 13.4.3 PAR and UVR Responses ............................................... 379 13.4.4 Nutrient Supply .............................................

2014
ZHI-YONG SHEN ZI-ZHEN ZHANG HUA LIU EN-HAO ZHAO HUI CAO

MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate the expression of targeted genes in a post-transcriptional manner. Increasing evidence indicates that miRNAs play important roles in cancer pathogenesis, including apoptosis, proliferation and differentiation, as oncogenes or tumor suppressors. Previously, miR-375 was shown to be involved in human gastric cancer, however, the m...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2013
Zhen-Wu Zhang Tong Men Rui-Cheng Feng Yun-Chao Li Di Zhou Chun-Bo Teng

BACKGROUND/AIMS The Hippo signaling pathway regulates expansion and differentiation of stem cells and tissue progenitor cells during organ development and tissue regeneration. Previous studies have shown that YAP1, a potent effector of the Hippo signaling pathway, plays a crucial role in pancreas development, but the function of YAP1 in pancreatic progenitor cells is less known. METHODS The s...

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