New regimens based on two or more novel agents are sought in order to shorten or simplify the treatment of both drug-susceptible and drug-resistant forms of tuberculosis. PA-824 is a nitroimidazo-oxazine now in phase II trials and has shown significant early bactericidal activity alone and in combination with the newly approved agent bedaquiline or with pyrazinamide with or without moxifloxacin...

Mouse monoclonal antibodies (MAbs) raised against whole cells of Staphylococcus epidermidis strain 354 were characterised morphologically and functionally. Nine MAbs showed strong reactivity with coagulase-negative staphylococci (CNS). Only two MAbs were specific for CNS; both belonged to the IgG1 subclass, and one, MAb 36.4, reacted only with the strain used for immunisation. In immunoblotting...

XPS and NRA depth profiling of nitrogen and carbon simultaneously 1 implanted into copper to synthesize C3N4 like compounds 2 J. L. Colaux, P. Louette , G. Terwagne 3 Research center in Physics of Matter and Radiation (PMR), 4 1 Laboratoire d’Analyses par Réactions Nucléaires (LARN), 5 2 Laboratoire Interdisciplinaire de Spectroscopie Electronique (LISE), 6 University of Namur (FUNDP), 7 61 Rue...

Deregulated microRNAs participate in carcinogenesis and cancer progression, but their roles in cancer development remain unclear. In this study, miR-365 expression was found to be downregulated in human colon cancer tissues as compared with that in matched non-neoplastic mucosa tissues, and its downregulation was correlated with cancer progression and poor survival in colon cancer patients. Fun...

Halldor Thormar*, Hilmar Hilmarsson and Gudmundur Bergsson Faculty of Life and Environmental Sciences, University of Iceland, Reykjavik, Iceland Department of Immunology, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland * Address correspondence to this author at the Faculty of Life and Environmental Sciences, University of Iceland, Sturlugata 7, 108 Reykjavik, Icelan...

OBJECTIVE This study aims to investigate the role and mechanism of miR-365 in the coronary atherosclerosis (AS). PATIENTS AND METHODS Blood were collected from AS patients and healthy people, coronary plaque and adjacent arterial tissue were collected from AS patients. QRT-PCR method was used to detect expressions of miR-365 and IL-6 in coronary plaque, blood monocytes, and serum. Western blo...

The purpose of this study was to determine whether aerosolized INS316 (UTP) stimulates lung mucociliary clearance (MCC) in sheep and, if so, to compare its effects with INS365, a novel P2Y(2)-receptor agonist. In the first series of studies, we used a previously described roentgenographic technique to measure tracheal mucus velocity (TMV), an index of MCC, before and for 4 h after aerosolizatio...