To investigate the effect of growth area on interface dislocation density in strained-layer epitaxy, we have fabricated 2-.um-high mesas of varying lateral dimensions and geometry in (001) GaAs substrates with dislocation densities of 1.5 X 10\ 10, and 10 cm-2 • 3500-, 7000-, and 8250-A-thick Ino (J5 Gao 95 As layers, corresponding to 5, to, and 11 times the experimental critical layer thicknes...

Background: Ataxia telangiectasia mutated and Rad3-related kinase (ATR) mediates cellular response to replication stress DNA damage. Camonsertib is a potent selective ATR inhibitor with strong pre-clinical efficacy, promising clinical activity (NCT04497116) but results in rapid monocytopenia leading dose limiting anemia potentially implicating disturbance iron homeostasis. Pre-clinically, dosin...

Shortened telomere length and decreased telomerase activity have recently been associated with perceived psychological stress and cardiovascular disease risk factors. The purpose of this study was to examine the relationship between exercise energy expenditure (EEE) and telomere length, telomerase activity, and hTERT genotype. Sixty-nine male (n = 34) and female (n = 35) participants 50-70 yr. ...

PURPOSE To investigate the false-positive activations/deactivations in functional MRI (fMRI) of deep brain stimulation (DBS) using a phantom. MATERIALS AND METHODS fMRI experiments were performed on a 1.5T scanner using a single-shot gradient-echo echo-planar imaging (GE-EPI) sequence (TR/TE/FA = 6000 msec/60 msec/90 degrees ) on an agar-gel phantom inserted with DBS electrodes. During the ex...

Multidrug resistance was an obstacle in cancer chemotherapy because the cells decreased their intracellular drug accumulation by energy-dependent compounds efflux pumps such as Pglycoprotein (P-gp). This study observed some iodinated radiographic contrast media, diatrizoate, iopromide and iotrolan affected the cellular energetic state and the kinetics of P-gp in drug-sensitive K562 and drug res...

A 66-year-old man presented with a white blood cell count of 62.63 10 /L. Peripheral blood (PB) smear showed 80% smallto medium-sized atypical lymphoid cells with irregular to cleaved (panel A; original magnification 3500, Wright-Giemsa stain) or binucleated nuclear contours, and slightly condensed chromatin (panel B; original magnification 31000, Wright-Giemsa stain). Bone marrow (BM) aspirate...

To search for unique mutations in the apolipoprotein B (apoB) gene that disrupt the binding of LDL to its receptor and cause hypercholesterolemia, we examined more than 800 patients with high LDL cholesterol levels and/or coronary artery disease (CAD). Analysis of patient DNA by single-strand conformation polymorphism and allele-specific oligonucleotide hybridization of the sequence surrounding...

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Background: Duchenne muscular dystrophy (DMD) is caused by a mutation in the dystrophin gene and most common form of childhood-onset affecting approximately 1 3500 newborn boys. The disease invariably progressive patients with DMD exhibit signs muscle weakness before 5 years age. Loss ability to walk usually occurs between 10 13 years. Despite all advances management treatment over last decades...

Human erythrocytes suspended in buffered isotonic saline were frozen to the temperature of liquid nitrogen at various cooling rates of 3, 140, 700, 1800, 3500, 8000 and 11 500 deg. C/min. The membrane ultrastructure in the frozen state and the extent of haemolysis after thawing were examined at each cooling rate. As the cooling rates increased from 3 to 3500 deg. C/min, the extent of lysis grad...