The chemokine receptor CXCR4 regulates cell migration during ontogenesis and disease states including cancer and inflammation. Upon stimulation by the endogenous ligand CXCL12, CXCR4 becomes phosphorylated at multiple sites in its C-terminal domain. Mutations in the CXCR4 gene affecting C-terminal phosphorylation sites are a hallmark of WHIM syndrome, a genetic disorder characterized by a gain-...

Abstract Aim To improve the rate of inclusion, and quality, important clinical details in ward round documentation General Surgery inpatients at a district general hospital. Method A 15-point checklist was created, containing which were considered appropriate to be included all wards entries. An initial audit 71 entries performed, assessing their compliance this checklist. Following this, profo...

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen with great ability to adapt stress, in particular, the selective pressure of antibiotics hospital environment. This constitutes real public health concern, especially low- and middle-income countries. In Cameroon, little known about drug resistance patterns aeruginosa. study sought determine prevalence strains producing carbapenem...

The purpose of this study was to determine the effect of self-stimulation of the parasympathetic nervous system on immune function and DNA repair function in family caregivers. Seven female family caregivers engaged in individually tailored stimulation of the parasympathetic nervous system in everyday life for 2 weeks. Although we observed effects on lymphocyte function and secretory immunoglob...