Background: HIV/AIDS resource allocation decisions are influenced by political, social, ethical and other factors that are difficult to quantify. Consequently, quantitative models of HIV/AIDS resource allocation have had limited impact on actual spending decisions. We propose a decision-support System for HIV/AIDS Resource Allocation (S4HARA) that takes into consideration both principles of eff...

The serial transverse enteroplasty (STEP) procedure is a novel technique to lengthen and taper the bowel in patients with short bowel syndrome. The advantages of STEP include not only technical ease and simplicity, but also the ability to repeat the procedure. Herein, we report a case of extreme short bowel syndrome that was successfully treated by the second STEP procedure. A 3-day old newborn...

the chemical speciation of heavy metals (arsenic, chromium, copper, lead, zinc and tin) in the sediments offormer tin mining catchment bestari jaya, peninsular malaysia was determined by using the latest version of the community bureau of reference, usually called the bcr 3-step sequential extraction procedure. furthermore, a fourth step was introduced for digestion and analysis of the residue....

This article concerns a problem still seldom studied, the two-echelon or two-level vehicle routing problem (LRP-2E). It is raised by distribution or collection networks involving two sets of vehicle trips: first-level trips serve from a main depot a set of satellite depots, which must be located, while second-level trips visit customers from these satellites. After a literature review on the LR...

This study redescribes an arthroscopic bridge technique for repair of avulsion of the posterior cruciate ligament. The procedure is performed step-to-step. In this technique we created two bone tunnels in the anterior aspect of the tibia and inferior medial of the tibia tuberosity and then create suture fixation of the fragment using the suture bridge. The arthroscopic bridge technique was used...

An extensive analysis of the Maria family is presented. A reconstruction of the original ejection velocity eld of the fragments suggests that a substantial amount of relatively large fragments has been probably injected into the neighbouring 3/1 mean motion resonance with Jupiter. This is also con rmed by an analysis of the size distribution of the family, suggesting that about 10 objects in th...

Dolutegravir, cabotegravir, and bictegravir are three integrase inhibitors, which were used for HIV-1 in the clinic. In this paper, a continuous three-step synthetic strategy was developed to prepare dolutegravir, better yield, compared initial step-by-step procedure. Different solvents, temperature, times optimized. course of industrial production active pharmaceutical ingredient (API), protoc...