F. Fiedler1, G. Shakirin1, J. Skowron1,4, H. Braess3, P. Crespo1,2, D. Kunath1,5, J. Pawelke1,5, F. Pönisch1,6, and W. Enghardt1,5 1FZD, Forschungszentrum Dresden-Rossendorf; 2now with: LIP, University of Coimbra, Portugal; 3Siemens Health Care, Particle Therapy; 4now with: IBA Dosimetry GmbH; 5also with: Oncoray Center for Radiation Research in Oncology; 6now with: The University of Texas MD A...

PURPOSE To analyze intraoperative (IO) dosimetry using transrectal ultrasound (TRUS), performed before and after prostate low-dose-rate brachytherapy (LDR-BT), and compare it to dosimetry performed 30 days following the LDR-BT implant (Day 30). MATERIAL AND METHODS A total of 236 patients underwent prostate LDR-BT using 125I that was performed with a three-dimensional TRUS-guided interactive ...

Computed tomography (CT) dosimetry normally uses an ionization chamber 100 mm long to estimate the computed tomography dose index (CTDI), however some reports have already indicated that small devices could replace the long ion chamber to improve quality assurance procedures in CT dosimetry. This paper presents a novel dosimetry system based in a commercial phototransistor evaluated for CT dosi...

Background: Craniospinal radiotherapy faces technical challenges which are due to the sensitivity of the location in which the gross tumor is, and to organs at risk around planning target volume. Using modern treatment planning systems causes a reduction in the complexities of the treatment techniques. The most effective method to assess the dosimetric accuracy and the validity of the ...

Radiopharmaceutical therapy (RPT) continues to demonstrate tremendous potential in improving the therapeutic gains radiation by specifically delivering tumors that can be well assessed terms of dosimetry and imaging. Dosimetry external beam is standard practice. This not case, however, RPT. NRG (acronym formed from first letter 3 original groups: National Surgical Adjuvant Breast Bowel Project,...

This study evaluates both the effects of physical restraint and use of candidate biomarkers in a CD2F1 male mouse partial-body irradiation model for biological dosimetry diagnostic assays. Mice were irradiated (6-Gy, 250-kVp X ray) to 3/3rd (total body), 2/3rd (gut and torso), 1/3rd (gut only) and 0/3rd (sham) of total body. Blood was sampled for haematology and blood plasma proteomic biomarker...

OBJECTIVE Iodine-131-labelled meta-iodobenzylguanidine (I-mIBG) therapy is an established treatment modality for relapsed/refractory neuroblastoma, most frequently administered according to fixed or weight-based criteria. We evaluate response and toxicity following a dosimetry-based, individualized approach. MATERIALS AND METHODS A review of 44 treatments in 25 patients treated with I-mIBG th...

The problem of choosing a prior distribution for the Bayesian interpretation of measurements (specifically internal dosimetry measurements) is considered using a theoretical analysis and by examining historical tritium and plutonium urine bioassay data from Los Alamos. Two models for the prior probability distribution are proposed: (1) the log-normal distribution, when there is some additional ...

background: megavoltage beams used in radiotherapy are contaminated with secondary electrons. different parts of linac head and air above patient act as a source of this contamination. this contamination can increase damage to skin and subcutaneous tissue during radiotherapy.  monte carlo simulation is an accurate method for dose calculation in medical dosimetry and has an important role in opt...

Purpose: To validate a locally fabricated phantom of Imatrixx-2D Array by comparing its results with ArcCheck phantom and comparing portal dosimetry measurements with the two phantom studies. Materials and Methods: Electronic Portal Imaging Devices and Epiqa software were used for portal dosimetry. An Imatrixx-2D array with a locally fabricated phantom and ArcCheck cylindrical phantom were used...