mono-targeting by imatinib as a main antitumor agent does not always accomplish complete cancer suppression. 2,5-dimethyl-celecoxib (dmc) is a close structural analog of the selective cyclooxygenase-2 (cox-2) inhibitor, celecoxib, that lacks cox-2 inhibitory function. in this study, we aimed to show the apoptotic effects of imatinib in combination with dmc in human ht-29 colorectal cancer (crc)...

background: radiation-induced bystander effect is a response which results in damage in non-irradiated cells in response to signals from the irradiated cells. the aim of the present study was to investigate microwave-induced bystander effect from a gsm mobile phone simulator on induction of apoptosis in jurkat cell line. materials and methods: jurkat cells were divided into three groups of non-...

introduction: oxidative stress and neuroinflammation are involved in neurodegeneration procedure in parkinson’s disease. recently, neuroprotective potential of boswellia resin has been demonstrated. therefore, this study examined whether administration of boswellia resin would attenuate mpp+- induced neuronal death in sk-n-sh- cell line, a human dopaminergic neurons- in vitro. methods: boswelli...

  Background and Objective: Pneumocystis pneumonia (PCP) has been historically the most prevalent opportunisticinfection in patients infected with the human immunodeficiencyvirus. Culture of the organism has not been faced with suitable success in artificial media, while various results have been reported for cell culture media. The aim of this study was proliferation of Pneumocystis carin...

Background: Plants are a proven source of anti-tumor compounds and it is reasonable to assume that many such substances remain to be discovered. In Iranian folk medicine, ethanolic extract of the aerial parts of Daphne mucronata Royle is used against various skin disorders.Objective: In order to evaluate anti-neoplastic plants, we initiated a cytotoxic study using Daphne mucronata that is indig...

nano-silver (agnp) has biological properties which are significant for consumer products, food technology, textiles and medical applications (e.g. wound care products, implantable medical devices, in diagnosis, drug delivery, and imaging). for their antibacterial activity, silver nanoparticles are largely used in various commercially available products. thus, the use of nano-silver is becoming ...

a green and efficient one-pot, four-component synthesis of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3- c ]pyrazo-carbonitrile derivatives catalyzed by borax in water is described. this method provides several advantages such as environmental friendliness, shorter reaction time, excellent yields, and simple workup procedure. the in vitro cytotoxic activity of the synthesized test compounds wa...

objective: prostate cancer is one of the most common cancer in the developed countries. most of cancer deaths are due to development of metastasis. hence, prevention of metastasis is critical. silibinin is a flavonoid component that inhibits cell proliferation and causes cell death of human prostate cancer. in this study, the expression of cd82 gene in pc-3 cells treated with escalating concent...

objective(s): glioblastoma is the most lethal tumor of the central nervous system. here, we aimed to evaluate the effects of exogenous delivery of p53 and a nanoformulation of curcumin called dendrosomal curcumin (dnc), alone and in combination, on glioblastoma tumor cells. materials and methods: mtt assay was exploited to measure the viability of u87-mg cells against dnc treatment. cells were ...