1. Hydrated electrons produced by pulse radiolysis were used to study the interaction of polyanionic glycosaminoglycans and related compounds with the counterions Methylene Blue and cetylpyridinium chloride. 2. The effect of added salt (potassium chloride) on the interaction indicates that the relative binding affinities, with respect to the types of anionic site present, increases for both cou...

When uninjured cells of Valonia are placed in methylene blue dissolved in sea water it is found, after 1 to 3 hours, that at pH 5.5 practically no dye penetrates, while at pH 9.5 more enters the vacuole. As the cells become injured more dye enters at pH 5.5, as well as at pH 9.5. No dye in reduced form is found in the sap of uninjured cells exposed from 1 to 3 hours to methylene blue in sea wat...

Mononuclear Zn(ii) complexes with the general formula [Zn(L)2] have been synthesized in good yields by reacting Zn(OAc)2 with HL in a ratio of 1 : 2 in methanol solvent. Here L is the deprotonated form of 6-[(quinolin-8-ylamino)methylene]cyclohexa-2,4-dienone (HL(1)), 4-chloro-6-[(quinolin-8-ylamino)methylene]cyclohexa-2,4-dienone (HL(2)), 4-methyl-6-[(quinolin-8-ylamino)methylene]cyclohexa-2,4...

1. A convenient synthesis of 24-methylene[23,25-(3)H(3)]dihydrolanosterol is described. 2. A general anaerobic-aerobic method for the incorporation of sterols into whole yeast cells is also described and illustrated by experiments with (3)H-labelled lanosterol. 3. The method was used to convert labelled 24-methylene-dihydrolanosterol into ergosterol, in good yield, by Saccharomyces cerevisiae. ...

Laboratory animals can develop serotonergic neurotoxicity after repeated doses of 3,4-methylenedioxymethamphetamine (MDMA) or ‘Ecstasy’. If similar neural damage occurs in humans, this may be evident in cognitive or behavioural impairments. In a review of the behavioural skills shown by drug-free recreational Ecstasy users, three aspects of cognitive performance are often affected: reduced memo...

1 The pressor responses produced by the intravenous administration of a,#-methylene ATP were tachyphylactic. 2 a,fi-Methylene ATP can attenuate pressor responses to sympathetic nerve stimulation both in the presence and in the absence of a-adrenoceptor blocking agents. 3 a,#-Methylene ATP has no effect on the pressor responses produced by bolus injections of noradrenaline. 4 In the presence of ...

The study aimed to synthesize and evaluate the potential anti-inflammatory analgesic activities of rationally designed hybrid molecules imidazolone indole nuclei linked through a methylene bridge. Indolyl-imidazolone hybrids were synthesized in three simple steps starting from 2-phenyl-1 H -indole ( 1 ). In first step, compound was converted -indole-3-carbaldehyde 2 ) using standard conditions ...

The reference standard CX-6258 {(E)-5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one, 4a} and its desmethylated precursor N-desmethyl-CX-6258 {(E)-3-((5-(3-(1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)-5-chloroindolin-2-one, 5} for radiolabeling were synthesized from 5-bromo-2-furaldehyde and 3-carboxybenzeneboronic acid in 3 and 4 steps wi...