Objective: To apply the principles of the Metro-ticket paradigm to develop a prognostic model for patients undergoing hepatic resection of colorectal liver metastasis (CRLM). Background: Whereas the hepatocellular ‘‘Metro-ticket’’ prognostic tool utilizes a continuum of tumor size and number, a similar concept of a CRLM Metro-ticket paradigm has not been investigated. Methods: Tumor Burden Scor...

Industrial engineers in the food-processing industry have developed the Halyard Analysis Critical Control Point (HACCP) system as a preventive approach to ensuring the safety of meat and poultry products. This paper discusses both the origins of HACCP as an engineering concept and the economics of HACCP as a regulatory tool. The authors contend that the economics literature has not adequately e...

BACKGROUND Food preferences vary substantially among adults and children. Twin studies have established that genes and aspects of the shared family environment both play important roles in shaping children's food preferences. The transition from childhood to adulthood is characterized by large gains in independence, but the relative influences of genes and the environment on food preferences in...

Background—Early diagnosis of nonacute heart failure is crucial because prompt initiation of evidence-based treatment can prevent or slow down further progression. To diagnose new-onset heart failure in primary care is challenging. Methods and Results—This is a cross-sectional diagnostic accuracy study with external validation. Seven hundred twenty-one consecutive patients suspected of new-onse...

Using quantitative gel retardation assays the properties of the bovine papilloma virus (BPV) origin recognition protein E1 and the effect of the viral E2 protein on the binding of E1 to BPV origin DNA were examined. As reported previously (Seo, Y.S., Mueller, F., Lusky, M., Gibbs, E., Kim, H.-Y., Phillips, B. and J. Hurwitz (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 2865-2869), the E1 protein b...

Androgen and androgen receptor (AR) play important roles in male spermatogenesis and fertility, yet detailed androgen/AR signals in Sertoli cells remain unclear. To identify AR target genes in Sertoli cells, we analyzed the gene expression profiles of testis between mice lacking AR in Sertoli cells (S-AR(-/y)) and their littermate wild-type (WT) mice. Digital gene expression analysis identified...

To cite: Bello Z. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014206826 DESCRIPTION A female baby was born at 24 weeks gestation, weighing less than 600 g. Owing to the extremely low birth weight and gestation age, she was at risk of developing sight threatening retinopathy of prematurity (ROP) 2 and therefore eligible for screening, which subsequently demons...

Recent estimates indicate that malaria has led to over half a million deaths worldwide, mostly to African children. Indoor residual spraying (IRS) of insecticides is one of the primary vector control interventions. However, current reporting systems do not obtain precise location of IRS events in relation to malaria cases, which poses challenges for effective and efficient malaria control. This...

The high-resolution solution structure of recombinant human basic fibroblast growth factor (FGF-2), a protein of 17.2 kDa that exhibits a variety of functions related to cell growth and differentiation, has been determined using three-dimensional heteronuclear NMR spectroscopy. A total of 30 structures were calculated by means of hybrid distance geometry--simulated annealing using a total of 28...

The accuracy of different coarse-resolution land cover products is an important consideration for product users at the regional or global scale, and different evaluation methods inevitably result in discrepancies in accuracy for the same land cover product. The remote sensing community has responded to this increased interest by improving methodologies for more accurately evaluating the correct...