3,4-Diaminopyridine (3,4-DAP) and its phosphate form, 3,4-DAPP have been used efficiently in the past years to treat muscular weakness myasthenic syndromes with neuromuscular junctions (NMJs) impairment. Pompe disease (PD), an autosomal recessive metabolic disorder due a defect of lysosomal enzyme α-glucosidase (GAA), presents some secondary symptoms that are related transmission dysfunction, r...

Objective: Synthesis and in vitro antimicrobial screening of 2,6-diaminopyridine Schiff bases isatin derivatives.
 Methods: Isatin it’s 5-substituted derivatives (S1-5) were prepared by Sandmeyer method N2-Benzylidenepyridine-2,6-Diamine (M) was obtained the reacting with benzaldehyde. (MS1-5) (M). Resultant compound structures confirmed some analytical techniques’ data. All synthesized sc...

Infertility is a very disastrous side effect in young females, especially in traditional male-dominated societies. The aim of this talk is to discuss the possible ways for fertility preservation in both man and woman. Another aspect is to how to predict women at threat of premature ovarian failure. It will also illustrate the association of cytochrome P450 (CYP2C19) polymorphism with ovarian to...