Shortening the duration of a Gaussian-shaped 2-kHz tone-pip causes the intensity-difference limen !DL" to depart from the ‘‘near-miss to Weber’s law’’ and swell into a mid-level hump #Nizami et al., J. Acoust. Soc. Am. 110, 2505–2515 !2001"$. For some subjects the size of this hump approaches or exceeds the size reported for longer tones under forward masking, suggesting that forward masking mi...

AIMS/BACKGROUND Pupillary light response is usually defective in all types of optic neuropathy. However, the authors have observed in patients with Leber's hereditary optic neuropathy (LHON) relatively normal light response, with consequent misdiagnosis psychogenic visual loss in some cases. To confirm this clinical impression, afferent pupillary defect was assessed by measurement of adjusted c...

OBJECTIVE To determine the prevalence and risk factors for suboptimal vitamin D status in Korean adolescents and to assess its relationship with atopic dermatitis (AD) and asthma at a national level. DESIGN This is a cross-sectional study with data from the Korean National Health and Nutrition Examination Survey. Information regarding socioeconomic characteristics, clinical data and environme...

BACKGROUND Previous prevention programs in the school context have not addressed both genders, have been time-consuming, or have had deficits in the evaluation method. The aim of the present study was to evaluate the impact of a universal prevention program for female and male adolescents on eating disorder pathology and related risk factors. METHODS Between February 2012 and July 2014, 2515 ...

OBJECTIVE The goal was to determine the association between cardiovascular risk factors and microalbuminuria in a nationally representative sample of adolescents and to determine whether being overweight modifies this association. METHODS We analyzed cross-sectional data from the National Health and Nutrition Examination Survey (1999-2004) for 2515 adolescents 12 to 19 years of age. Cardiovas...

OBJECTIVE To examine potential associations between socioeconomic factors and self-rated health among a national sample of Japanese men aged 50-59 years between 2005 and 2010, including the 2008 global financial crisis. DESIGN Prospective cohort study. SETTING Randomly selected 2515 census areas from a total of 1.8 million census areas in Japan. PARTICIPANTS This study utilised data from ...

OBJECTIVES To determine age- and sex-specific reference values for six physical performance measures, i.e. hand-grip strength, one-legged stance, and gait speed and step length at both usual and maximum paces, and to investigate age and sex differences in these measures among community-dwelling older Japanese adults. METHODS We conducted a pooled analysis of data from six cohort studies colle...

n engl j med 368;26 nejm.org june 27, 2013 2515 1. Styne DM, Grumbach MM. Puberty: ontogeny, neuroendocrinology, physiology and disorders. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams textbook of endocrinology. 12th ed. Philadelphia: Elsevier Saunders, 2001:1054-201. 2. Gluckman PD, Bergstrom CT. Evolutionary biology within medicine: a perspective of growing value. BMJ 201...

CONTEXT The high percentage of failed clinical trials in depression may be due to high placebo response rates and the failure of standard statistical approaches to capture heterogeneity in treatment response. OBJECTIVE To assess whether growth mixture modeling can provide insights into antidepressant and placebo responses in clinical trials of patients with major depression. DESIGN We reana...