In recent years, circulating miRNAs have attracted interest as stable, non-invasive biomarkers for various pathological conditions. Here, we investigated their potential to serve as minimally invasive, early detection markers for inflammatory breast cancer (IBC) and non-inflammatory breast cancer (non-IBC) in serum. miRNA profiling was performed on serum from 20 patients with non-IBC, 20 with I...

OBJECTIVE To examine the effect of various combinations of beverages on hydration status in healthy free-living adult males. METHODS In a counterbalanced, crossover manner, 18 healthy adult males ages 24 to 39, on four separate occasions, consumed water or water plus varying combinations of beverages. Clinical guidelines were used to determine the fluid allowance for each subject. The beverag...

BACKGROUND AND AIMS Oral lichen planus is a relatively common chronic oral mucosal disease of unknown etiology. Regarding numerous studies on the immunologic factors involved in the etiology of lichen planus, the present study evaluated the serum interleukin-17 (IL-17) level in patients with erosive and non-erosive oral lichen planus. MATERIALS AND METHODS This descriptive analytical study in...

_______________ WARNINGS AND PRECAUTIONS_______________ May cause somnolence: After taking HETLIOZ, patients should limit their activity to preparing for going to bed, because HETLIOZ can impair the performance of activities requiring complete mental alertness (5.1) ___________________ ADVERSE REACTIONS ___________________ The most common adverse reactions (incidence >5% and at least twice as h...

BACKGROUND None of current diagnostic methods has been proven to be a reliable tool for gastro-esophageal reflux disease (GERD). Pepsin in saliva has been proposed as a promising diagnostic biomarker for gastro-esophageal reflux. We aimed to determine the diagnostic value of salivary pepsin detection for GERD. METHODS Two hundred and fifty patients with symptoms suggestive of GERD and 35 asym...

INTRODUCTION Physical activity is known to significantly impact cardiometabolic health. Accelerometer data, as a measure of physical activity, can be used to objectively identify a disparity in movement (movement discordance) between healthy and unhealthy adults. The purpose of this study was to examine the Movement Discordance between healthy and unhealthy adults in a large US population sampl...

The commentator suggests that it is necessary to extend the classical connotation of  global city which focuses much on the functions of controlling global capital and production. Global city should also include the dimensions of the leading role and capacity on health improvements and well-being promotion. The commentator agrees with authors’ assessments about Shanghai’s substantial progress o...

OBJECTIVE To investigate functional hemodynamic response to passive leg raising in healthy pregnant women and compare it with non-pregnant controls. MATERIALS AND METHODS This was a prospective cross-sectional study with a case-control design. A total of 108 healthy pregnant women at 22-24 weeks of gestation and 54 non-pregnant women were included. Cardiac function and systemic hemodynamics w...