Growing evidences indicated that Long noncoding RNAs (lncRNAs) played important roles in tumor initiation and progression. However, the function and mechnism of lncRNA ferritin heavy chain 1 pseudogene 3 (FTH1P3) remain unknown in uveal melanoma. We showed that the expression level of FTH1P3 was upregulated in uveal melanoma cell lines and tissues. Elevated expression of FTH1P3 promoted uveal m...

The metastatic spread of tumor cells is the major risk factor affecting the clinical prognosis of colorectal cancer (CRC) patients. The metastatic phenotype can be modulated by dysregulating the synthesis of different structural and functional proteins of tumor cells. Micro(mi)RNAs are noncoding RNAs that recognize their cognate messenger (m)RNA targets by sequence-specific interactions with th...

Malignant melanoma is highly lethal due to its aggressive invasive properties and metastatic dissemination. The transcription factor E2F1 is crucial for melanoma progression through poorly understood mechanisms. Here, we show that the miR-224/miR-452 cluster is significantly increased in advanced melanoma and invasive/ metastatic cell lines that express high levels of E2F1. miR-224/miR452 expre...

MicroRNAs (miRNAs) are between 19 and 25 mer non‑coding RNAs involved in cancer cell proliferation, apoptosis, stress responses and maintenance of stem cell potency. In the present study, miR‑224 was observed to be upregulated in colorectal cancer (CRC) tissue. Overexpression of miR‑224 facilitated proliferation of the CRC cell lines, HCT‑116 and SW‑480. Bioinformatics analysis revealed a putat...

Type 1 iodothyronine deiodinase (DIO1) catalyses the conversion of prohormone thyroxine to the active thyroid hormone 3,3',5-triiodothyronine (T3), important regulator of cell proliferation and differentiation. DIO1 expression is reduced in the most common type of kidney neoplasia, clear cell Renal Cell Carcinoma (ccRCC). MicroRNAs are small, non-coding RNAs that regulate gene expression at pos...

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The objective of this project is to analyze the performance of a class-based language model and compare it to the performance of traditional n-gram language models. Class-based language models are well-studied, as is the use of clustering to learn classes of words. However, it seems fairly standard across the literature to use hard-clustering i.e. assign each word to a single class and then to ...

PURPOSE Copper in serum supports angiogenesis and inhibits replication of wild-type HSV-1. Copper chelation is currently being investigated as an antiangiogenic and antineoplastic agent in patients diagnosed with cancer. Herpes simplex virus-derived oncolytic viruses (oHSV) are being evaluated for safety and efficacy in patients, but several host barriers limit their efficacy. Here, we tested w...

http://jmg.bmj.com/content/41/3/224.full.html Updated information and services can be found at: These include: References http://jmg.bmj.com/content/41/3/224.full.html#related-urls Article cited in: http://jmg.bmj.com/content/41/3/224.full.html#ref-list-1 This article cites 20 articles, 4 of which can be accessed free at: service Email alerting the top right corner of the online article. Receiv...

UNLABELLED The development of a PET radioligand selective for I2-imidazoline binding sites (I2BS) would enable, for the first time, specific, measurable in vivo imaging of this target protein, along with assessment of alterations in expression patterns of this protein in disease pathophysiology. METHODS BU99008 was identified as the most promising I2BS radioligand candidate and radiolabeled w...