0377-2217/$ see front matter 2008 Elsevier B.V. A doi:10.1016/j.ejor.2008.09.037 * Tel.: +90 312 2901702. E-mail address: [email protected]. In this study, we analyze the replenishment decisions under a general replenishment cost structure that includes stepwise freight costs and all-units quantity discounts. We first formulate a general model that accounts for a larger class of problems an...

Example 1. In a genetic study, n = 2217 patients are recruited, among which 1127 have bladder cancer. After whole genome sequencing, p = 475290 single nucleatide polymorphisms (or SNPs, a possible variation of the DNA sequence at one location) are measured on each patient. We construct a matrix X = (Xij)1≤i≤n,1≤j≤p where Xij = 1 if the ith patient has a mutation at jth location and 0 otherwise....

0377-2217/$ see front matter 2008 Elsevier B.V. A doi:10.1016/j.ejor.2008.03.001 * Corresponding author. Tel.: +1 519 888 4567x339 E-mail addresses: [email protected] (L. Fu), vkim@ This paper introduces a real-time optimization model that can be used by maintenance managers to develop and evaluate alternative resources allocation plans for winter road maintenance operations. The model takes int...

* Author for correspondence: Head of Discipline, Discipline of Microbiology and Immunology, M502 School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, 35 Stirling Hwy, Crawley WA 6009, Australia. Tel: (08) 9346 2217, Fax: (08) 9346 2912, Email: [email protected]. Abstract. The persistence of highly pathogenic avian influenza virus within wild bird ...

The ability to program recombinant gene expression in cardiac myocytes in vivo holds promise for the treatment of many inherited and acquired cardiovascular diseases. In this report, we demonstrate that a recombinant P-galactosidase gene under the control of the Rous sarcoma virus promoter can be introduced into and expressed in adult rat cardiac myocytes in vivo by the injection of purified pl...

Fixation durations in reading are longer for within-word fixation positions close to word center than for positions near word boundaries. This counterintuitive result was termed the Inverted-Optimal Viewing Position (IOVP) effect. We proposed an explanation of the effect based on error-correction of mislocated fixations [Nuthmann, A., Engbert, R., & Kliegl, R. (2005). Mislocated fixations durin...

0377-2217/$ see front matter 2010 Elsevier B.V. A doi:10.1016/j.ejor.2010.09.009 ⇑ Tel.: +1 781 861 6279. E-mail address: [email protected] We propose and develop an efficient implementation of the robust tabu search heuristic for sparse quadratic assignment problems. The traditional implementation of the heuristic applicable to all quadratic assignment problems is of O(N) complexity per iteration ...

System setup. All vesicles were obtained by spontaneous aggregation of randomly placed lipids. This method is described in detail elsewhere [1]. An additional long equilibration run of 20 μs was performed for the mixed lipid systems (two artificial pores were present) [2]. In all cases, equilibrium of the vesicle was defined by the flux convergence of the lipid components. The pure POPC vesicle...

0377-2217/$ see front matter 2009 Elsevier B.V. A doi:10.1016/j.ejor.2009.04.007 * Tel.: +1 305 348 3309; fax: +1 305 348 4126. E-mail address: [email protected] We review the latest theoretical developments for the single-machine total tardiness 1== T scheduling problem and propose extensions to some of them. We also review (and in some cases extend) exact algorithms, fully polynomial time appr...