BACKGROUND The objective of the study was to investigate the activity of sunitinib in a cell line model and subsequently in patients with cisplatin-refractory or multiply relapsed germ cell tumors (GCT). METHODS The effect of sunitinib on cell proliferation in cisplatin-sensitive and cisplatin-refractory GCT cell lines was evaluated after 48-h sunitinib exposure by MTT [3-(4,5-dimethylthiazol...

............................................................................................................................................................3 INTRODUCTION ..................................................................................................................................................5 1.1 APPLICATION AREA AND MOTIVATION ...........................................

The incidence rate in the UK increased from 109 per million population (pmp) in 2013 to 115 pmp in 2014 reflecting renal replacement therapy (RRT) initiation for 7,411 new patients. The increase in incidence rate from 2013 to 2014 was seen in England and Scotland (although rates in Scotland have fluctuated around this level since 2008) but not Wales and Northern Ireland. The median age of all i...

BACKGROUND Total arch replacement (TAR) is being more widely performed due to recent advances in operative techniques and cerebral protective strategies. In this study, the authors reviewed the relationship between TAR and early- and mid-term changes of the false lumen after TAR in acute type A aortic dissection. MATERIALS AND METHODS Twenty-six patients (aged, 54.7±13.3 years) who underwent ...

OBJECTIVE The purpose was to determine the effect of vaginal pessaries in patients at risk for spontaneous preterm birth (SPB). STUDY DESIGN Transvaginal sonography (TVS) was longitudinally performed to measure cervical length (CL) in 258 singleton at risk for SPB and 282 twin pregnancies. Pairs with or without treatment were matched for gestational age and the CL at examination. RESULTS In...

Abstract Aim The British Society of Gastroenterology (BSG) recommends biopsies from two different regions in the oesophagus. A close loop audit was undertaken to assess performance at a district general hospital, against these guidelines and following newly agreed trust after first cycle follow up OGD within 6 weeks presentation. Method Data collected patients admitted with food bolus over (Mar...

BACKGROUND Structured examination routines have been developed as educational resources for musculoskeletal clinical skills teaching, including Gait-Arms-Legs-Spine (GALS), Regional Examination of the Musculoskeletal System (REMS) and paediatric GALS (pGALS). In this study, we aimed to assess the awareness and use of these examination routines in undergraduate medical teaching in UK medical sch...

Université de Caen Basse Normandie LUSAC EA-2607, Groupe Vision et Analyse d'Images 120, route de l'exode, 50000 Saint-Lô, France Phone : +33 (0)2 33 77 55 11 Fax : +33 (0)2 33 77 11 67 E-mail: [email protected] Université Laval Département de génie électrique et de génie informatique Laboratoire de Vision et de Syst emes Numériques Pavillon Pouliot Quebec, QC, Canada, G1K 7P4 Phone: (...

Aims/Objectives/Background According to safety theory, frontline staff are often best informed identify problems that threaten in their workplace. Surveying emergency department (ED) is a straightforward method assess culture including investigating risks, identifying solutions and evaluating interventions. This study‘s aim was validate an ED questionnaire specifically for use the UK provide ov...