Myeloid differentiation 88 (MyD88) is the key signaling adapter of Toll-like and interleukin-1 receptors. Recurrent lymphoma-associated mutations, particularly Leu265Pro (L265P), within the MyD88 Toll/interleukin-1 receptor (TIR) domain sustain lymphoma cell survival due to constitutive nuclear factor κB signaling. We found that mutated TIR domains displayed an intrinsic propensity for augmente...

Method for data fusion between Microwave Scanning Radiometer: MSR and Thermal Infrared Radiometer: TIR derived skin sea surface temperature: SSST, wind speed: WS and salinity is proposed. SSST can be estimated with MSR and TIR radiometer data. Although the contribution ocean depth to MSR and TIR radiometer data are different each other, SSST estimation can be refined through comparisons between...

Space-time TIR anomalies, observed from months to weeks before earthquake occurrence, have been suggested by several authors as pre-seismic signals. Up to now, such a claimed connection of TIR emission with seismic activity has been considered with some caution by scientific community mainly for the insufficiency of the validation data-sets and the scarce importance attached by those authors to...

The Toll/interleukin-1 receptor (TIR) domain is a protein-protein interaction domain that is found in both animal and plant immune receptors. The N-terminal TIR domain from the nucleotide-binding (NB)-leucine-rich repeat (LRR) class of plant disease-resistance (R) proteins has been shown to play an important role in defence signalling. Recently, the crystal structure of the TIR domain from flax...

The importance of the Escherichia coli O157:H7 translocated intimin receptor (Tir) protein in intestinal colonization and the effect of infection with Tir+ strains on protection against subsequent challenge was studied in adult beef cattle. Cattle were orally inoculated (C1) with a Shiga toxin-2+ E. coli O157:H7 strain that was Tir+ or Tir−, and 42 days later were re-challenged (C2) with the na...

Purpose To introduce a new model of telescopic intramedullary rod (TIR), evaluate its effects on treating patients presenting with moderate and severe osteogenesis imperfecta (OI) and to compare the findings with those of other telescopic rods. Methods A total of 21 patients (nine girls and 12 boys; mean age at first operation, 6.6 years, 1.52 to 13.18) who underwent 52 femoral operations wer...

The family of resistance gene analogues (RGAs) with a nucleotide-binding site (NBS) domain accounts for the largest number of disease resistance genes and is one of the largest gene families in plants. We have identified 868 RGAs in the genome of the apple (Malus × domestica Borkh.) cultivar 'Golden Delicious'. This represents 1.51% of the total number of predicted genes for this cultivar. Seve...

Total internal reflection (TIR) Raman and reflectivity spectra were collected for nonresonant analytes as a function of incident angle at sapphire or sapphire/smooth 50 nm gold interfaces using 785 nm excitation. For both interfaces, the Raman signal as a function of incident angle is well-modeled by the calculated interfacial mean square electric field (MSEF) relative to the incident field tim...

0099-1112/08/7403–0 /$3.00/0 © 2008 American Society for Photogrammetry and Remote Sensing Abstract In this study, we developed a land-cover classification methodology using Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) visible near-infrared (VNIR), shortwave infrared (SWIR), and thermal infrared (TIR) band combinations based on wavelet fusion and the selforganizing map...

BACKGROUND Emerging molecular, animal model and epidemiologic evidence suggests that Shiga-toxigenic Escherichia coli O157:H7 (STEC O157) isolates vary in their capacity to cause human infection and disease. The translocated intimin receptor (tir) and intimin (eae) are virulence factors and bacterial receptor-ligand proteins responsible for tight STEC O157 adherence to intestinal epithelial cel...