the current short term phase (data taking completed in years 2007-8) we are studying the ratio RK = Γ(K→eνe(γ)) Γ(K→μνμ (γ)) of leptonic decay rates, which provides a golden probe for testing the structure of the weak interactions. In the second phase (long term) we will then focus on the measurement of the branching ratio of the very rare kaon decay K+ → π+νν̄ aiming at collecting O(100) K+→ π+...

T development of a systematic design process for synthetic gene regulatory networks is an intriguing prospect that could improve both our understanding of regulatory motifs and our techniques for constructing novel applications. Such a design process would entail analysis tools capable of reliably predicting the in vivo behavior resulting from a given regulatory architecture. As with the proces...

M ultivesicular bodies (MVBs) are specialized endosomes that promote the degradation of membrane proteins by delivering them to lysosomes. This process is regulated by a series of endosomal sorting complexes required for transport (ESCRTs) (1). The ESCRT-0,-I, and-II complexes sequester ubiquitinated membrane proteins and recruit the ESCRT-III complex to drive the invagination and release of ca...

Many real-world analytics problems involve two significant challenges: prediction and optimization. Due to the typically complex nature of each challenge, the standard paradigm is to predict, then optimize. By and large, machine learning tools are intended to minimize prediction error and do not account for how the predictions will be used in a downstream optimization problem. In contrast, we p...

CA) reveal that DNA is synthesized when it is least likely to be hit with oxidative damage. Damaging oxidizing agents are produced by respiration. In yeast, respiration is periodic—it alternates in ‫ف‬ 40-min cycles with a stage of non-respiration called the reductive phase. This oscillation was detected decades ago, but it was never thought to be connected to cell cycle progression. Now, Kleve...