OBJECTIVES There are differences in symptoms, risk stratification, and efficacy of pharmacological treatments between men and women with coronary artery disease (CAD). The results of clinical studies of cell therapy in CAD patients are mixed. The relevance of sex to response to cell therapy is unknown. We investigated sex-based differences in response to bone marrow mononuclear cells (BM-MNCs) ...

trichomoniasis, a worldwide prevalent infection, is a perfect example of interplay between the infecting parasite and the host, on which the presentation of disease depends. to study the pathogenesis, animal model is required for establishment of infection. in this study, by using strains of trichomonas vaginalis isolated from vaginal swabs and/or urine samples and maintained in axenic form fro...

background: heroin as opium is being used in two pure and impure forms with known disastrous effects on different body organs including genital system. the aim of this study was to determine the changes in testosterone secretion, the percentage of fertility, changes of the body and testis weight, and gonado somatic index in mice (ballb/c). materials and methods: a total of 90 adult male and fem...

The effects of dietary restriction (DR) on the activities of liver superoxide dismutase (SOD), catalase (Cat), and glutathione peroxidase (GPX) and the level of lipid peroxidation (LP) in developing mice were investigated in this study. Male and female Kunmin mice were fed a standard rodent diet ad libitum (AL), 80% of AL food intake (20% DR), or 65% of AL food intake (35% DR) for 12 or 24 wk. ...

To investigate the sensitivity of heterozygous p53-deficient CBA mice to carcinogens, 20 female mice [p53(+/-)] and 20 wild-type littermates [p53(+/+)] were given an intraperitoneal injection of 120 mg/kg body wt of N-ethyl-N-nitrosourea (ENU) and were maintained without any other treatment for a further 26 weeks. Histopathology showed that uterine tumors (endometrial polyps and stromal sarcoma...

Elastase 1-sitnian virus transgenic mice, strain Tg(Ela-l, SV40E) Bril8, were studied to characterize the development of pancreatic neo plasms. The incidence of pancreatic carcinomas was compared in groups of male and female mice fed one of three diets chosen because of their effect on the development of pancreatic carcinomas in other animal models. Male mice developed more exocrine carcinomas ...

background: there are reports about the increase of severity of infections in patients receiving morphine. therefore this study was aimed to evaluate the effect of morphine on phagocytic activity of peritoneal phagocytes of mice. methods: fifty six female balb/c mice, 6-8 weeks old and 28±2 gram weight, were divided into two groups. the case group received 20, 40, 60 and 80 mg/kg morphine on fi...

A bioassay of 2,4,5-trimethylaniline for possible carcinogenicity was conducted by administering the test chemical in feed to F344 rats and B6C3F1 mice. Groups of 50 rats and 50 mice of each sex were administered 2,4,5-trimethylaniline at one of two doses, either 200 or 800 ppm for the rats and either 50 or 100 ppm for the mice, for 101 weeks. Matched controls consisted of 20 untreated rats and...

Proton Pump Inhibitor-Induced Gut Dysbiosis has been demonstrated in previous studies and was associated with poor prognosis patients received immunotherapies chemotherapies. However, little is known about the influence of dysbiosis on efficacies target therapies like epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). We conduct a study to elucidate role PPI related EGFR-T...