نتایج جستجو برای: 2 substituted benzimidazoles
تعداد نتایج: 2550956 فیلتر نتایج به سال:
A water soluble, Bronsted acid, 5-sulfosalicylic acid as an efficient organocatalyst was used for the synthesis of physiologically active 2-substituted benzimidazole derivatives from o-phenylenediamine and aromatic aldehydes in ethanol at reflux condition. Cost-effectiveness, use of non-hazardous solvents, metal free and commercially available catalyst, single-step, environmentally fri...
phospho sulfonic acid (psa) synthesized as an environmentally safe and efficient solid acid catalyst, and it used for the synthesis of several 2-disubstituted benzimidazoles, 2-substituted benzoxazoles, and 2-substituted quinoxalines in ethanol as a green solvent at ambient temperature is described. (i) a very simple, green and efficient procedure for the synthesis of benzimidazole and also benz...
Novel 2-substituted-6-[(4-substituted-1-piperidyl)methyl]-1H-benzimidazoles were designed and synthesized as Ebola virus inhibitors. The proposed structures of the new prepared benzimidazole-piperidine hybrids confirmed based on their spectral data CHN analyses. target compounds screened in vitro for anti-Ebola activity. Among tested molecules, 26a (EC50=0.93 ?M, SI = 10) 25a (EC50=0.64 20) pot...
Mixed crystals of 1-(4-chlorophenylsulfonyl)-2,5-dimethyl-1 H -benzimidazole and 1-(4-chlorophenylsulfonyl)-2,6-dimethyl-1 (ratio 0.707:0.293; two molecules in the asymmetric unit), 0.707C 15 13 ClN 2 O S·0.293C S, ( I ), 2- n -butyl-1-(4- tert -butylphenylsulfonyl)-5-chloro-1 -butylphenylsulfonyl)-6-chloro-1 [ratio 0.731 (2):0.269 (2); one molecule unit], 0.731C 21 25 S·0.269C II were obtained...
Phospho sulfonic acid (PSA) synthesized as an environmentally safe and efficient solid acid catalyst, and it used for the synthesis of several 2-disubstituted benzimidazoles, 2-substituted benzoxazoles, and 2-substituted quinoxalines in ethanol as a green solvent at ambient temperature is described. (i) A very simple, green and efficient procedure for the synthesis of benzimidazole and also benz...
Diversity-oriented synthesis of novel benzimidazole linked indolo-benzodiazepine/quinoxaline ring systems using poly(ethylene glycol) as soluble polymer support is described. Commercially available 4-fluoro-3-nitrobenzoic acid and indoline were utilized for the construction of these annulated biheterocyclic compound libraries having multiple privileged structures with three-point structural div...
Microorganism-caused diseases are one of the greatest predicaments faced by world. The disease conditions worsened due to development microbial resistance against numerous antimicrobial agents like quinolones, vancomycin, macrolides, tetracyclines, β-lactam antibiotics, etc. There will always be a vital need discover new chemotherapeutic avert emergence and ideally shorten duration therapy...
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