Two novel 3-amino-5-(4-choloro-2-phenoxyphenyl)-4H-1,2,4-triazole derivatives were prepared and their anticonvulsant activity was measured by evaluation of the ability of these compounds to protect mice against convulsion induced by lethal doses of pentylenetetrazole (PTZ). Diazepam (Sigma) was considered as a positive control drug with anticonvulsant effect [ED50 = 1.2 (0.5-1.9) mg/Kg]. Amongs...

The synthesis of 2-amino-2-chromenes under solvent-free conditions is disclosed here using a silica triflate catalyzed one-pot three component condensation. product was obtained in outstanding yield the optimal reaction range functionalized aromatic aldehydes, malononitrile, and α/β-naphthol. This procedure stands out for its wide substrate scope, reduced time, great yield, functional group com...

Objective: Many methods can be found in literature for the synthesis a Oxazines and Thiazines. Few are reported one-pot multi component cyclo-condensation of an alkayane urea / Thiourea Aldehyde to 2- amino-4H-1, 3-Oxazines or Different catalysts like Trifluoro-acetic acid, glacial acetic acid under reflux condition Mandal Co-workers have utilized perchloric (HClO4) supported on silica gel as c...

We have reported a microwave assisted base directed regioselective synthesis of partially reduced chromenes, isochromenes and phenanthrenes. Functionalized 4-(piperidin-1-yl)-5,6-dihydro-2H-benzo[h]-chromen-2-one-3-carbonitriles have been used as precursors, which on reaction with functionalized acetophenones in the presence of KOH in DMF under microwave irradiation yield (Z)-2-(2-aryl-5,6-dihy...

A new recoverable molybdenum nanocatalyst was prepared by immobilization  of a Schiff base ligand on the surface of silica coated magnetite nanoparticles (Fe3O4@SiO2) through condensation reaction between 3-aminopropyl triethoxysilane and 2-hydroxy1-naphthaldehyde and succeeding reaction with dioxomolybdenum(VI) acetylacetonate (MoO2(acac)2). The synthesized cat...

The structural motif that results from the fusion of a benzene ring to a heterocyclic pyran ring, known as chromene, is broadly found in nature and it has been reported to be associated with a wide range of biological activity. Moreover, asymmetric organocatalysis is a discipline in expansion that is already recognized as a well-established tool for obtaining enantiomerically enriched compounds...