It has been postulated that the perfused rat hindlimb is unsuitable for measurements of muscle glucose transport [P. Hansen, E. Gulve, J. Gao, J. Schluter, M. Mueckler, and J. Holloszy. Am. J. Physiol. 268 ( Cell Physiol. 37): C30-C35, 1995]. The aim of the present study was therefore to critically evaluate the suitability of this preparation for glucose transport measurements using the extrace...

2-Deoxy-D-glucose uptake was studied in the normal, insulin-treated, and streptozotocin-induced diabetic rat lung. Using an isolated perfused lung preparation, 2deoxy-o-glucose uptake was enhanced by insulin and depressed by diabetes. The uptake of 2-deoxy-o-glucose was inhibited by both phloridzin and cytochalasin B. Further, the uptake process was found to be stereospecific with L-glucose upt...

1,3,4,6-Tetra-O-acetyl-2-(di-2-chloroethyl)amino-2-deoxy-D-glucopyranose is active against L1210 leukemia, giving over 100% increased life-span at optimal dose. Against P388 leukemia, it gives 200% increased life-span with long-term survivors. The compound is most active when given i.p., but shows some activity when given s.c. than p.o., and is more potent (therapeutic and toxic effect) than me...

The physiological factors which determine the penetration of the brain by 2-deoxy-D-glucose have been studied and the practical importance of the blood-brain barrier has been demonstrated. The evaluation of the gastric secretory response to 2-deoxy-D-glucose has been shown to depend upon the plasma glucose concentration. It is concluded that because of the hazards and uncertainties in the use o...

The temperature-dependent and concentration-dependent 1H NMR studies as well as 13C-relaxation experiments on gilvocarcin V tetraacetate strongly suggest intermolecular stacking of the antibiotic solution.

As a relatively uncommon disease in clinical practice, Hodgkin’s lymphoma of the nasopharynx is particularly susceptible to misdiagnosis, which might delay treatment. Clinical dilemmas are regularly faced attempt forecast this disease. With aim developing flawless prediction system future raise rate early diagnosis and enhance patient prognosis, we primarily highlight several about tumor microe...