A series of novel pyranochromene-containing tetrazoles fused with pyrimidinethiones, pyrimidines, and diazepines 3a-f, 4a-f, and 5a-f were synthesized by condensation of the corresponding tetrazoles 2a-f with carbon disulfide, benzaldehyde, and 4-methoxy phenacyl bromide, respectively. The compound 2a-f was obtained by reaction of pyrano[3,2-c]chromenes 1a-f with sodium azide. The structures of...

Montmorillonite KSF has been used as an effective and non-toxic heterogeneous catalyst for one-pot synthesis of 5-substituted 1H-tetrazoles via [3+2] cycloaddition of sodium azide with a wide variety of nitriles. The reaction afforded high yields of the desired products in a short reaction time under mild reaction conditions. The catalyst can be recovered by simple filtration and reuse...

The synthesis and characterization of new 4-[(2-alkyl)-2H-tetrazol-5-yl]phenyl 4-alkyloxybenzoates (5a–i) and 5-{4-[(4-substituted)benzyloxy]phenyl}-2-alkyl-2H-tetrazoles (7a–e) are reported. The reported tetrazoles contain two alkyl chains (six to ten carbon atoms) except for 5h and 7e which have a chiral citronellyl group linked at the N-2 nitrogen atom of the tetrazole ring and 5i having a b...

A variety of aldehydes reacted with iodine in ammonia water at room temperature to give the nitrile intermediates, which were trapped by addition of hydrogen peroxide, sodium azide, or dicyandiamide to produce their corresponding amides, tetrazoles, and 1,3,5-triazines in modest to high yields. The one-pot tandem reactions were conducted in water media, and the products were obtained simply by ...

During this study the application of Natrolite zeolite was investigated as a solid acid catalyst for efficient preparation of 5substituted 1H-tetrazole derivatives. Excellent yields of products were obtained with a wide range of substrates. After completion of the reaction, the catalyst was recovered by filtration and reused several times with only a slight decrease of activity observed under t...

New tetrazole analogues with bio-active cores have been synthesized by a novel synthetic methodology. The synthesized compounds were characterized using FT-IR, MS, elemental analysis, H, C and HSQC NMR spectroscopic techniques. The synthesized compounds were screened for their antibacterial activities against Staphylococcus aureus, Escherichia coli, Vibreo cholerae, Pseudomonas aeruginosa and K...