The conventional search for an effective two-body interaction to be used in shellmodel studies involves numerically intensive mixed configuration calculations. It is, however, now known that meaningful averages of effective interaction matrix elements can be obtained through an alternative simpler method with the help of energy-weighted sum rules 1), 2), 3), 4), 5), 6). Monopole energy weighted...

Six novel members of the IL-1 family of cytokines were recently identified, primarily through the use of DNA database searches for IL-1 homologues, and were named IL-1F5 to IL-1F10. In the present study, we investigated the effect of IL-1F8 on primary human joint cells, and examined the expression of the new IL-1 family members in human and mouse joints. Human synovial fibroblasts (hSFs) and hu...

Abstract Female sex steroid hormones have been shown to interact with cytokines within the immune system help influence fertility. Previous research has indicated that shifts in commensal bacteria are associated compromised reproductive performance during postpartum period, yet evaluation of how female hormone progesterone (P4) influences these microbial is not fully understood. The objectives ...

An 879.9(2) keV γ -ray transition has been identified following the β decay of 58V and assigned as the 21 → 01 transition in Cr34. A peak in the energies of the first excited 2 + states for the even–even chromium isotopes is now evident at Cr32, providing empirical evidence for a significant subshell gap at N = 32. The appearance of this neutron subshell closure for neutron-rich nuclides may be...

CD27, a member of the tumor necrosis factor receptor superfamily, is constitutively expressed on the majority of mature T cells, memory B cells, and a subset of NK cells. We previously demonstrated anti-tumor and immunological properties of the fully human anti-CD27 mAb 1F5 (CDX-1127) in murine tumor models of hematologic and solid tumors. A Phase I dose escalation study of CDX-1127 in patients...

The classification of abnormalities of glucose tolerance introduced in 1979 by the National Diabetes Data Group and agreed by the World Health Organisation included the category of impaired glucose tolerance.' 2 The diagnosis depends on the blood glucose concentration two hours after a glucose load being above normal (6-7 mmol/l) and below the new diabetic value (10 mmol/l). This category satis...

S chizophrenia and affective psychoses are severe and prevalent psychiatric disorders described in all cultures and populations. Whether these functional psychoses are two distinct disorders, or are closely related in aetiology, has been debated in the literature during the last century. Several studies have suggested that schizophrenia and bipolar disorder are on a continuum of liability. Psyc...

Recently, deeply bound pionic states were found experimentally in (d,He) reactions on Pb. The observed spectrum showed an excellent agreement with the DWIA calculation and the dominant peak was attributed to the pionic 2p state contribution. We studied theoretically Pb(d,He) reactions within the same model, and found that it is very likely to observe the pionic 1s state as an isolated peak in t...

Carlet. J. Clement. H. Demarne, M. Mellet. J.-P. Richaud, D. Segondy. M. Vedel, J:P. Gagnol. R. Roncucci, B. Castro. P. Corvol. G. Evin. B. P. Roques, ibid. 1986, 29, 1152-1159: d) H . Mazdiyasni. D. B. Konopacki, D. A. Dickman, T. M. Zydowsky, Tetruhedron Lett. 1993, 34, 435-438. [4] a) M . Frankel. P. Moses. Tetrahedron 1960.9.289-294: h) W. F. Gilmore, H.-J. Lin. J. Org. Chem. 1978, 43. 4535...

We address the two main questions relevant to microscopic nuclear structure calculations starting from a free NN potential. These concern the accuracy of these kinds of calculations and the extent to which they depend on the potential used as input. Regarding the first question, we present some results obtained for nuclei around doubly magic Sn and Pb by making use of an effective interaction d...