Since the launch of ChemistryOpen in 2011, more and more governments are mandating publicly funded research results to be made available in an open-access form; the main idea being that scientific research should be available to the public free of charge to allow creative and innovative research. The Research Councils UK (RCUK) mandated that from April 1st, 2013 all publications resulting from ...

BACKGROUND Breaches of publication ethics such as plagiarism, data fabrication and redundant publication are recognised as forms of research misconduct that can undermine the scientific literature. We surveyed journal editors to determine their views about a range of publication ethics issues. METHODS Questionnaire sent to 524 editors-in-chief of Wiley-Blackwell science journals asking about ...

BACKGROUND Tumor markers are widely applied in clinical practice, however, few serum markers have been found for intracranial tumors. Herein, we firstly report an intracranial epidermoid cyst case with extremely high level of serum CA 199. Furthermore, the relationship between CA 199 level and intracranial epidermoid cyst was closely followed for a long period. CASE PRESENTATION We report a c...

The regulation of Mcl-1 expression is necessary for the induction of cancer cell apoptosis by ABTs such as ABT-737, ABT-263 and ABT-199. However, the reduction in Mcl-1 expression is not sufficient for initiating cell death in hematopoietic cancer cells with high Bcl-xL expression. Here, we demonstrate that 2-deoxyglucose (2-DG) enhanced the effect of ABT-199 to induce cell apoptosis in hematol...