Purpose To conduct a simplified lesion-detection task of low-dose (LD) PET-CT protocol for frequent lung screening using 30% the effective PETCT dose and to investigate feasibility increasing clinical value low-statistics scans machine learning. Methods We acquired 33 SD PET images, which 13 had actual LD (ALD) PET, simulated (SLD) images at seven different count levels from scans. employed ima...

Background: A 2-deoxy-2-[18F]fluoro-D-glucose (FDG) is useful for early metabolic response assessment in various malignancies, including Colorectal Cancer (CRC). Herein, we express that Positron Emission Tomography/Computed (PET-CT) with FDG was very useful for early diagnosis, accuracy and additional value of whole-body in recurrent CRC. Case Report: A 50 years old woman was diagnosed with an ...

Choriocarcinoma (CC) is the highest malignant gestational trophoblastic tumor which causes high mortality without timely treatment. HIF-1α is a very important molecule promoting neoplasm aggressiveness, metastasis through the induction of the epithelial to mesenchymal transition (EMT). Several researches have shown that Notch signaling is necessary for coupling hypoxia to the EMT. However, the ...

The purpose of the study was to assess physiologic endometrial 18F-FDG uptake during the 4 phases of the menstrual cycle and to differentiate between physiologic and malignant endometrial uptake. Methods: Endometrial 18F-FDG uptake, expressed as standardized uptake value (SUV), was measured on PET/CT images of 285 consecutive female patients, of whom 246 (112 premenopausal and 134 postmenopausa...

A 35-y-old woman with pyrexia of unknown origin was referred to the Nuclear Medicine Department for an 18FFDG PET scan. She had undergone heart–lung transplantation for secondary pulmonary hypertension 4 mo previously. After transplantation she developed organizing pneumonia proven on transbronchial biopsies for which she required treatment with pulsed methyl prednisolone. Three months after su...

Abstract Introduction HER2 over-expression denotes poor prognosis in breast cancers.Bone morphogenetic protein(BMP) signalling is known to interact with EGF signalling, co-regulating cancer progression.BMP antagonist Gremlin-1 may influence disease progression, but this remains unexplored positive cancers. Method GREM1 and expression, clinical outcomes were examined cohorts.GREM1 overexpression...

Objectives: Clinical approach of prostate cancer (PCa) biochemical recurrence (BCR) is an ever-changing topic. Prostate-specific membrane antigen positron emission tomography ([68Ga]Ga-PSMA-11 PET-CTPSMA PET-CT) has shown good potential in this field. The aim to evaluate PSMA PET-CT detection rate PCa BCR and assess its impact on clinical outcome. Material methods: Out 319 patients with who und...

Merkel cell carcinoma (MCC) is a rare, aggressive, cutaneous neuroendocrine neoplasm, the presentation of which varies. Histologically it is a dermic lesion. Differentiation of the cells is difficult to distinguish from cutaneous metastases of neuroendocrine carcinomas, melanoma and angiosarcoma. The immunohistochemical profile of MCC and its ultrastructural characteristics help to differentiat...