Background Information on the bioavailability of the essential mineral Mg2+ is sparse. Objective/Method Evaluation of the present knowledge on factors influencing the bioavailability and intestinal absorption of Mg2+. Results Mg2+ is absorbed via a paracellular passive and a transcellular active pathway that involves TRPM6/7 channel proteins. The bioavailability of Mg2+ varies within a broa...

The K+-insensitive component of Mg2+ influx in primary culture of ruminal epithelial cells (REC) was examined by means of fluorescence techniques. The effects of extracellular anions, ruminal fermentation products, and transport inhibitors on the intracellular free Mg2+ concentration ([Mg2+]i), Mg2+ uptake, and intracellular pH were determined. Under control conditions (HEPES-buffered high-NaCl...

Although the role of calcium (Ca2+) in the signal transduction and pathobiology of the exocrine pancreas is firmly established, the role of magnesium (Mg2+) remains unclear. We have characterized the intracellular distribution of Mg2+ in response to hormone stimulation in isolated mouse pancreatic acinar cells and studied the role of Mg2+ in modulating Ca2+ signaling using microspectrofluoromet...

In non Mg(2+)-loaded and non malaria-infected rat erythrocytes, mefloquine (100 micromol x l (-1)) stimulated choline/Mg2+ antiport without affecting the Na+/Mg2+ antiport. The stimulation of the choline/Mg2+ antiport by mefloquine, found in this study, and by trifluoperazine and fluvoxamine, reported previously [Ebel et al. Biochim Biophys Acta 2004; 1167: 132-40], was associated with CF3 grou...

We explore the halo structure of four gravitational lenses with well-observed, thin Einstein rings. We find that the gravitational potentials are well described by ellipsoidal density distributions in the sense that the best-fit nonellipsoidal models have parameters consistent with their ellipsoidal counterparts. We find upper limits on the standard parameters for the deviation from an ellipse ...

We develop a theory of Einstein rings and demonstrate it using the infrared Einstein ring images of the quasar host galaxies observed in PG 1115+080, B 1608+656 and B 1938+666. The shape of an Einstein ring accurately and independently determines the shape of the lens potential and the shape of the lensed host galaxy. We find that the host galaxies of PG 1115+080, B 1608+656 and B 1938+666 have...

OBJECTIVE To show the effect of hypokinesia (HK; diminished movement) on magnesium (Mg2+) loss in Mg2+ deficient subjects and the effect of physical exercise and on Mg2+ deficiency with and without physical exercise: Mg2+ balance, serum Mg2+ concentration and Mg2+ loss were measured. METHODS Studies were conducted on 30 healthy male volunteers during a pre-experimental period of 30 days and a...