Liver radioembolization is a treatment option for unresectable liver cancers, performed by infusion of 90Y or 166Ho loaded spheres in the hepatic artery. As tumoral cells are mainly perfused via artery unlike lobules, twofold tumor to normal dose ratio commonly obtained. To improve cell killing while preserving co-infusion arterial vasoconstrictor has been proposed but with limited success: buf...

introduction:holmium-166 radionuclide is one of the most effective radionuclides used for targeted therapy with theranostic properties. one method to produce this radioisotope is via the decay of its parent (indirect method). in this study applicability of extraction chromatography (exc) for separation of no carrier added 166ho from neutron-irradiated natural dysprosium target followed by quali...

OBJECTIVE(S) In this study, (166)Ho-1,2-propylene di-amino tetra(methy1enephosphonicAcid) ((166)Ho-PDTMP) complex was prepared as a bone palliation agent. MATERIALS AND METHODS The complex was successfully prepared using an in-house synthesized EDTMP ligand and (166)HoCl3. Ho-166 chloride was obtained by thermal neutron irradiation (1 × 1013 n.cm-2.s-1) of natural Ho(NO3)3 samples followed by...

Holmium-166 microspheres are used for the transarterial radioembolization (TARE) treatment of primary and secondary liver cancers. In this study, its efficacy regarding local tumor control integration into oncological sequence first 20 patients treated in our institution were examined. A total twenty-nine 166Ho-TARE procedures performed to treat hepatocellular carcinoma (HCC, fourteen patients)...