introduction:the use of beta emitters is one of the effective methods for palliation of bone metastasis. the risk of normal tissue toxicity should be evaluated in the bone pain palliation treatment. methods: in this study, the monte carlo simulation code mcnpx was used for simulation a bone phantom model consisted of bone marrow, bone and soft tissue. specific absorbed fractions were calculated...

REPLY: We would like to thank Drs. Lam and Smits for their concerns and comments regarding the methodology in our study (1). The aim of our study was to answer the frequently occurring clinical question of whether a patient with low or no 99mTcmacroaggregated albumin (99mTc-MAA) uptake in metastatic lesions should undergo 90Y-radioembolization. The observation in our patient cohort with colorec...

Introduction: Recently, 166Ho-BPAMD was introduced as a suitable agent for bone marrow ablation. The aim of this study was to estimate the absorbed dose of this novel agent in the human organs which is necessary before the clinical application. Methods: 166Ho was produced by direct irradiation of 165Ho in the research reactor. 250 µg...