INTRODUCTION Increasing evidence indicates that microRNAs (miRNAs) play a critical role in the pathogenesis of inflammatory diseases. The aim of the study was to investigate the expression pattern and function of miRNAs in CD4+ T cells from patients with rheumatoid arthritis (RA). METHODS The expression profile of miRNAs in CD4+ T cells from synovial fluid (SF) and peripheral blood of 33 RA p...

MicroRNAs are short non-coding RNAs that regulate gene expression and are crucial to tumorigenesis. Oral squamous cell carcinoma (OSCC) is a prevalent malignancy worldwide. Up-regulation of miR-146 has been identified in OSCC tissues. However, the roles of miR-146 in carcinogenesis are controversial as it is suppressive in many other malignancies. The present study investigated the pathogenic i...

Activation of the T cell-mediated immune response has been associated with changes in the expression of specific microRNAs (miRNAs). However, the role of miRNAs in the development of an effective immune response is just beginning to be explored. This study focuses on the functional role of miR-146a in T lymphocyte-mediated immune response and provides interesting clues on the transcriptional re...

background and purpose: micrornas are small non-coding rnas with 1924- nucleotides in length. up- or downregulation of many mirnas has been shown by stimulation of toll-like receptors (tlrs) in the innate immune system. up-regulation of mir-146a has been reported by both tlr and heat-killed candida albicans. in this study, we aimed to evaluate the expression of mir-146a in cultured monocyte-der...

epilepsy is the third most common chronic brain disorder which is characterized by an enduring predisposition to generate seizures. mesial temporal lobe epilepsy (mtle) is the most common type of refractory epilepsy. increasing evidence indicates that neuroinflammation plays a critical role in the pathogenesis of mtle. hundreds of micro-rnas have been found to be abnormally expressed in epilept...

The aim of the present study was to observe the effect of zhenbao pill on the motor function of acute spinal cord injury (ASCI) rats and the molecular mechanisms involving miR-146a-5p and G-protein-coupled receptor 17 (GPR17). ASCI rat model was established by modified Allen method, and then the rats were divided into three groups. SH-SY5Y cells were cultured overnight in hypoxia condition and ...

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a strong genetic predisposition, characterized by an upregulated type I interferon pathway. MicroRNAs are important regulators of immune homeostasis, and aberrant microRNA expression has been demonstrated in patients with autoimmune diseases. We recently identified miR-146a as a negative regulator of the interferon pathway ...

We indented to evaluate of the role miRNA-146a-5p expression level as a possible biomarker associated with incidence rheumatoid arthritis and detection its relevance different disease parameters. The study included 60 clinically diagnosed RA patients fulfilling 2010 American College Rheumatology / European League Against Rheumatism (ACR/EULAR) classification criteria for Rheumatoid Arthritis 45...

The impairment in diabetic wound healing represents a significant clinical problem. Chronic inflammation is thought to play a central role in the pathogenesis of this impairment. We have previously shown that treatment of diabetic murine wounds with mesenchymal stem cells (MSCs) can improve healing, but the mechanisms are not completely defined. MicroRNA-146a (miR-146a) has been implicated in r...