BACKGROUND Foreign-born patients with tuberculosis (TB) may introduce globally disseminated isolates of Mycobacterium tuberculosis into large cities in Japan. The risk of dissemination of these isolates into local regions, however, has not been determined. This study analyzed the molecular epidemiology of M. tuberculosis isolates obtained from TB patients living in a local region of Japan. ME...

Manuscript information: 21 pages ; 2 figures, 1 table ; 111 words in the abstract; 3945 words in the main text.

The first structurally authenticated [2+2] cycloaddition products of any transition metal hydrazide complexes are reported; cycloaddition products of transition metal hydrazides with alkynes and heteroalkynes have been obtained for the first time; these are the first structurally authenticated cycloaddition products for any transition metal M=NNR(2) functional group.

This work presents the desymmetrization of oxabenzonorbornadienes through (3+2) cycloaddition reaction with hydrazones using a chiral Brønsted acid such as BINOL-derived phosphoramide. catalyst appears most effective mediator for activation hydrazone via hydrazonium cation that reacts in fashion oxabenzonorbornadiene olefinic counterpart. Under optimized conditions, provided selectively exo pro...

Less than two years after the discovery of high temperature superconductivity in oxypnictide LaFeAs(O, F) several families of superconductors based on Fe layers (1111, 122, 11, 111) are available. They share several characteristics with cuprate superconductors that compromise easy applications, such as the layered structure, the small coherence length and unconventional pairing. On the other ha...

Mathematical models of fullerenes are cubic planar maps with pentagonal and hexagonal faces. As a consequence of Eulers’s formula the number of pentagons in such a map is 12. Conversly, for any integer α ≥ 0, there exists a fullerene map with precisely α hexagons unless α = 1. In this paper, we consider hyperbolic analogues of fullerenes, which are defined as cubic maps of face-type (6, k) on o...

312 radiology.rsna.org Radiology: Volume 264: Number 2—August 2012 1 From the Department of Radiology (W.R.H., M.K.O.), Section of Nuclear Medicine (M.K.O.), Mayo Clinic, 725 11th St NW, Rochester, MN 55901. From the 2011 RSNA Annual Meeting. Received December 16, 2011; revision requested February 2, 2012; revision received February 10; accepted March 16; final version accepted April 13. Addres...

Alkylidenepyrrolidines 1, 21, 24 and 26 undergo reactions with nitrile oxides and nitrilimines or their precursors to give a range of novel heterocyclic compounds. With alkylidenepyrrolidine ester 1, nitrolic acids give products in which the liberated nitrous acid reacts with the alkylidenepyrrolidine, followed by two cycloadditions to give adducts 3. In contrast, hydroximoyl chlorides give iso...

The first transannular [4 + 2] cycloaddition reactions of macrocyclic dicobalt hexacarbonyl-dienyne complexes were demonstrated. Complexes were conveniently prepared through palladium(II)-catalyzed intramolecular oxidative cyclization of bis(vinylboronate esters) followed by complexation with dicobalt octacarbonyl. Transannular [4 + 2] cycloaddition reactions of the complexes occurred at lower ...

We previously demonstrated that Bothrops jararaca venom (BjV) has an antitumor effect on Ehrlich ascites tumor (EAT) cells and induces an increase of polymorphonuclear leukocytes in early stages of tumor growth. It has been reported that this venom presents an important inflammatory effect when inoculated in animal models and in human snakebites, and that cytokine levels have been detected in t...