Little is known about the potential role of T cells in the inflammatory renal disease glomerulonephritis (GN). GN has been historically viewed as a product of immune complex-mediated complement activation, and the presence of autoantibodies made identifying T cell-specific effector contributions difficult to elucidate. In this issue of the JCI, Heymann et al. generate what they believe to be a ...

The silicide Li13.7Rh8Si18.3 was synthesized from the elements in a sealed niobium ampoule at 1370 K followed by slow cooling. The sample was studied by powder and single-crystal X-ray diffraction. Li13.7Rh8Si18.3 crystallizes with a non-centrosymmetric occupancy variant of the R-phase structureMg32(Al, Zn)49: I23, a = 1306.9(2) pm,wR2 = 0.0447, 1286 F2 values, and 53 variables. Striking struct...

Human aromatase is responsible for the last step of estrogen biosynthesis, for the aromatization of ring A of androstenedione (ASD) or testosterone. In this work the mechanism of aromatization was studied using gas phase and hybrid QM/MM calculations. It is shown that human aromatase can efficiently catalyze the aromatization process via a Compound I (or Compound II) mediated pathway. The natur...

1389-1286/$ see front matter 2014 Elsevier B.V. All rights reserved. http://dx.doi.org/10.1016/j.bjp.2013.12.037 q GENI is funded by the U.S. National Science Foundation. Any opinions, findings, conclusions or recommendations expressed in this material are the authors’ and do not necessarily reflect the views of the National Science Foundation. ⇑ Corresponding author. Tel.: +1 617 873 3675. E-m...

1389-1286/$ see front matter 2012 Elsevier B.V. All rights reserved. http://dx.doi.org/10.1016/j.comnet.2012.12.001 ⇑ Corresponding author. Tel.: +55 32 2102 3311. E-mail addresses: [email protected] (A.B. Vieira), rafael.barra@ ice.ufjf.edu.br (R.B. de Almeida), [email protected] (J.M. de Almeida), [email protected] (S.V.A. Campos). 1 This statistic was extracted from an article enti...

Traveling waves u(x st) for systems of conservation laws ut + Df(u)ux = (B(u)ux)x were studied by Majda and Pego (J. Di erential Eqs. 56 (1985), 229{262) under the assumption that u( 1) and u(+1) are close. Their results were recently extended to general convection-di usion systems ut +A(u)ux = (B(u)ux)x by Sainsaulieu (SIAM J. Math. Anal. 27 (1996), 1286{1310). Sainsaulieu's proofs use xed-poi...