A spontaneous mutation affecting locomotion of the nematode Caenorhabditis elegans has been mapped to a new gene, unc-119. Phenotypic characterization of the mutants suggests the defect does not lie in the musculature and that the animals also have defects in feeding behavior and chemosensation. unc-119 has been physically mapped relative to a previously identified chromosomal break in linkage ...

PURPOSE NY-ESO-1 (ESO), a tumor-specific antigen of the cancer/testis group, is presently viewed as an important model antigen for the development of generic anticancer vaccines. The ESO(119-143) region is immunodominant following immunization with a recombinant ESO vaccine. In this study, we generated DRB1*0101/ESO(119-143) tetramers and used them to assess CD4 T-cell responses in vaccinated p...

The isomer shift for the 23.87 keV M1 resonant transition in the (119)Sn nucleus is calibrated with the help of ab initio calculations. The calibration constant alpha((119)Sn) obtained from Hartree-Fock (HF) calculations (alpha(HF)((119)Sn) = (0.081+/-0.002)a(0)(-3) mm/s) and from second-order Moller-Plesset (MP2) calculations (alpha(MP2)((119)Sn) = (0.091+/-0.002)a(0)(-3) mm/s) are in good agr...