This work describes the syntheses and antitumoral properties of five prenyl compounds from which antiproliferative activities were predicted by using the TOPS-MODE approach, a computational method for drug design. The syntheses of 2-(3-methylbut-2-enyloxy)acetophenone (2), 2-hydroxy-5-(3-methylbut-2-enyl)acetophenone (3), 2-hydroxy-3-(1,1-dimethylallyl)acetophenone (4), and 5-(3-methylbut-2-eny...

T-61 is an agent used for euthanasia of animals and is primarily administered by iv injection. When so used it rapidly induces deep anesthesia and cerebral death. We report our findings in a case of ingestion of T-61 with suicidal intent. The coroner's report stated that the individual survived for 20 to 30 min and that death was due to cardio-respiratory failure. Levels of embutramide in the b...

This paper examines how the concept of 'excessive costs' has been interpreted in the implementation of industrial pollution control in the UK. Since 1984, industrial air pollution regulation in the EU has been guided by the framework concept of Best Available Technology Not Entailing Excessive Costs (BATNEEC). With the introduction of the Integrated Pollution Prevention & Control Directive in 1...

In 1964, Albretch Fleckenstein described an inhibitory action ofverapamil and prenylamine on excitation-contraction coupling that was similar to calcium depletion. By the late 1970s, the clinical use of calcium channel blockers (CCBs) was widely accepted for variety of cardiovascular indications, including hypertension, dysrhythmias, and angina. Later indications, including Raynaud phenomenon, ...

Of the four heart valves, three are tricuspid (aortic, pulmonic, and tricuspid) and one is bicuspid (mitral). Failure of normal function of these valves is due to lesions that make them incompetent and allow backward flow (regurgitation) or to lesions that decrease orifice size and cause restriction of flow (stenosis). In addition, combinations of these lesions may occur within the same valve, ...

One of the major mechanisms involved in acetaminophen (APAP)induced hepatotoxicity is hepatocyte nuclear factor 4a (HNF4a)mediated activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR). In the present study, we investigated the role of miR-561 and its target gene DAX-1 encoding a corepressor of HNF4a in the process of APAP-induced hepatotoxicity. We used both human ...

cited—that of mothers aged 15–19 with partners aged 20 or older; in their study, 65% of 15–19-year-old mothers had a partner aged 20 or older.5 Males and Chew took a similar conceptual approach, identifying “school-aged” mothers (ages 10–18) and their non–school-aged partners (19 or older).6 Grouping together 15–19-year-olds and their partners ages 20 and older may misrepresent the issue of ado...

Previous studies have revealed an increased fractional anisotropy and greater thickness in the anterior parts of the corpus callosum in meditation practitioners compared with control subjects. Altered callosal features may be associated with an altered inter-hemispheric integration and the degree of brain asymmetry may also be shifted in meditation practitioners. Therefore, we investigated diff...

We review the organization of the neural networks that underlie haptic object processing and compare that organization with the visual system. Haptic object processing is separated into at least two neural pathways, one for geometric properties or shape, and one for material properties, including texture. Like vision, haptic processing pathways are organized into a hierarchy of processing stage...