INTRODUCTION There is increasing interest in the control and elimination of schistosomiasis. Little is known, however, about the likely effects of increasing water-body temperatures on transmission. METHODS We have developed an agent-based model of the temperature-sensitive stages of the Schistosoma and intermediate host snail life-cycles, parameterised using data from S. mansoni and Biomphal...

Many important learning problems, from a wide variety of domains, involve learning from imbalanced data. Because this learning task is quite challenging, there has been a tremendous amount of research on this topic over the past fifteen years. However, much of this research has focused on methods for dealing with imbalanced data, without discussing exactly how or why such methods work—or what u...

This thesis addresses the mechanism of electromotility in outer hair cells (OHCs) of the mammalian cochlea. Prestin, a protein densely packed in the lateral membrane is assumed to drive electromotility. A current hypothesis is that prestin is an incomplete transporter, shuttling chloride across the membrane without allowing it to dissociate at the extracellular surface. In this thesis kinetic m...

Initial studies of dementia due to lobar atrophy (Pick's disease and Dementia of the Frontal Lobe Type, DFT) indicate neurochemical profiles distinct from that of Alzheimer's disease (AD) [1,2]. We have examined the cortical serotonergic profile of previously frozen human brains from control patients (n=27, 178: 1 O? , age 68 f 10 yrs, postmortem delay (PMD) 30 f 20 hrs, mean f s.d.) and patien...

Abstract Introduction High quality sleep is crucial to health and development in children. Compared healthy children, hospitalized children have a higher chance of experiencing disrupted poor-quality sleep, which may thereby impede their recovery. There lack research around disruptors outside the ICU setting. Methods This IRB approved, prospective, survey-based study was completed 2022 included...

objective: although much is known about estrogen and progesterone, their toxicity or protective effects on hepatocytes are yet to be fully understood. this study investigated the probable oxidant or antioxidant effects of estrogen and progesterone on hepg2 cell line in the presence or absence of h2o2. methods: hepg2 cells were cultured with two concentrations of estrogen and progesterone (10pm ...