Human African trypanosomiasis (HAT) is caused by the protozoan Trypanosoma brucei. New drugs are needed to treat HAT because of undesirable side effects and difficulties in the administration of the antiquated drugs that are currently used. In human proliferative diseases, protein tyrosine kinase (PTK) inhibitors (PTKIs) have been developed into drugs (e.g., lapatinib and erlotinib) by optimiza...

The antibacterial activities of levofloxacin, erythromycin, and rifampin against intracellular Legionella pneumophila L-1033, serogroup 1, were studied. In an in vitro system utilizing adherent human monocytes, L. pneumophila L-1033, a phagocytosis time period of 1 h, and antibiotic (levofloxacin, erythromycin, and/or rifampin) at 1 to 10 times the MIC, the CFU/ml values for the monocyte lysate...

تم استخدام أنظمة المعلومات الجغرافية (GIS) على نطاق واسع لأنه اعتبارها أداة قوية جدًا ومهمة وضرورية في التطبيقات الهندسية مثل دراسة تآكل التربة. هذه الدراسة الاستشعار عن بعد (RS) ونظام من أجل تحديد القيم ورسم خرائط التوزيع المكاني للتعرية المطرية (R) لحوض نهر حرير. حيث تبلغ مساحة 350.03 كم2 وتقع بين خط عرض (36° 20' 00" N to 36° 40' N) وخط طول (44° 10' E 44° 30' E) ويتراوح ارتفاع حوض حرير 366 م إ...

We present an early vision of a system that allows computer controlled rendering of physical surfaces, terrains, and environments by manipulating grids of “physical pixels” or rods whose heights can be raised and lowered on command. A user would be free to walk within such a dynamically deformable physically rendered environment (PRE). The system would be able to create on demand the floor, cei...

BACKGROUND The role of erbB tyrosine kinases, especially Her-2, in osteosarcoma has engendered intense debate. Some investigators identified an association between low-level Her-2 expression, compared to none, and poor patient outcome. Others questioned the importance of apparent cytoplasmic expression of Her-2, since membranous overexpression is associated with poor outcome in carcinomas. We p...