Paxillin and vinculin are cytoskeletal proteins that colocalise to focal adhesions, specialised regions of the cell involved in attachment to the extracellular matrix. These two molecules form part of a complex of proteins that link the actin network to the plasma membrane. Paxillin has been shown to bind directly in vitro to the C-terminal region of vinculin (Turner et al. (1990). J. Cell Biol...

BACKGROUND Postoperative heart failure remains the major cause of death after cardiac surgery. As N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a predictor for postoperative heart failure, the aim was to evaluate if preoperative NT-proBNP could provide additional prognostic information to the recently launched EuroSCORE II. METHODS A total of 365 patients with acute coronary syndro...

High-rate core-to-core communication is critical for efficient pipeline-parallel software architectures. This paper presents the FastForward system, a software-only lowoverhead high-rate queue implementation for pipeline parallelism on multicore architectures. FastForward uses an architecturally-tuned domain-specific adaptation of concurrent lock-free queues to provide low-latency and lowoverhe...

Cystic fibrosis (CF), the most common life-shortening, hereditary disease in whites, manifests itself principally in childhood. Patients presenting with CF as adults appear to be different when compared to patients diagnosed with CF during childhood. Often these patients have been previously diagnosed with asthma, chronic bronchitis or emphysema. We present a case of a woman diagnosed with CF a...

Cystic fibrosis (CF) is an inherited disease that primarily affects the lungs and the digestive system, however, it also affects a number of other organs and systems. More than 90% of mortality of  CF patients is due to lung complications.  Healthy lungs are important for a long life for people with CF, We will discuss two important topics for maintaining respiratory health. Chronic use of drug...

cystic fibrosis (cf), the most common life-shortening, hereditary disease in whites, manifests itself principally in childhood. patients presenting with cf as adults appear to be different when compared to patients diagnosed with cf during childhood. often these patients have been previously diagnosed with asthma, chronic bronchitis or emphysema. we present a case of a woman diagnosed with cf a...