A NIR-chemometric method, that is able to directly quantify the active pharmaceutical ingredient (API) and two major excipients in pharmaceutical powder blends for manufacturing indapamide sustained release (SR) tablets, was developed and fully validated. In order to develop calibration models for the assay of indapamide, hydroxypropylmehylcelulose (HPMC) and lactose, the NIR spectra of 25 seri...

The development of NIRS calibration model as a rapid, precise, robust, and cost-effective method to estimate oil content in ground seeds of worldwide safflower germplasm collection grown under different agro-climatic conditions was the key objective of this research project. The oil content was measured by accelerated solvent extraction method in a total of 328 samples collected across 2004 (16...

Introduction: The key characteristics of positron emission tomography (PET) are its quantitative capability and its sensitivity, which allow the in vivo imaging of biochemical interactions with small amounts of tracer concentrations. Therefore, accurate quantification is important. However, it can be sensitive to several physical factors. The aim of this investigation is the assessment of the e...

The influence of particle size on near-infra red (NIR) spectra is typically considered a 'nuisance factor' which many scatter correction methods attempt to eliminate, e.g., multiplicative scatter correction. However, particle size is a key issue in the formulation of many pharmaceutical products and has a profound effect on the behaviour of both raw materials and drug substances during formulat...

The extraction of chemical information from dense particulate suspensions, such as industrial slurries and biological suspensions, using near-infrared (NIR) spectroscopic measurements, is complicated by sample-to-sample path-length variations due to light scattering. Empirical pre-processing techniques such as multiplicative scatter correction (MSC), extended MSC, and derivatives have been appl...

The growth quality of Pinus massoniana (Lamb.) seedlings is closely related to the survival rate afforestation. Moisture content detection an important indicator in cultivation forest because it can directly reflect adaptability and potential soil environment. To improve accuracy quantitative analysis moisture P. using near-infrared spectroscopy, a total 100 were collected, their diffuse reflec...

The use of near infrared (NIR) spectroscopy for predicting levels of degradation in southern pine (Pinus spp.) by Gloeophyllum trabeum for periods over 1-8 da was investigated. NIR spectra collected from the center of the radial face of each sample after laboratory soil block decay tests were used to develop calibrations. Calibrations were developed for mass loss, compression strength, and expo...

Introduction: Scattered photon is one of the main defects that degrade the quality and quantitative accuracy of nuclear medicine images. Accurate estimation of scatter in projection data of SPECT is computationally extremely demanding for activity distribution in uniform and non-uniform dense media. Methods: The objective of this paper is to develop and validate a scatter correction technique ...